一名患有混合性结缔组织病的 63 岁中国女性,曾出现肾危象

IF 0.7 4区 医学
Jiasheng Shao, Jiayan Liu, Qiang Guo, Liou Cao
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引用次数: 0

摘要

混合性结缔组织病(MCTD)是一种罕见的自身免疫性疾病。我们介绍了一例中国女性病例,她曾先后八次入住我院。她最初的症状涉及肺部和心脏等内脏器官。由于存在抗 U1RNP 抗体和其他临床特征,考虑诊断为 MCTD。在第一次至第七次住院期间,她的血清肌酐水平一直保持正常。在第八次住院期间,她的肾功能迅速恶化,最终出现肾危象。胸部计算机断层扫描(CT)证实了肺水肿,因此必须进行血液透析。在整个住院期间,她的白细胞介素(IL)-6 水平显著升高。患者对 IL-6 受体拮抗剂(IL-6RA)的治疗反应良好。该病例提出了一个问题:IL-6 是否可作为预测 MCTD 患者肾危象发生率的潜在生物标志物?
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A 63-year-old Chinese female with mixed connective tissue disease who suffered from renal crisis
Mixed connective tissue disease (MCTD) is a rare autoimmune disorder. We present a case of a Chinese female who has been admitted to our hospital on eight separate occasions. Her initial symptoms involved internal organs including the lung and heart. Due to the presence of anti-U1RNP antibodies and other clinical features, a diagnosis of MCTD was considered. Throughout her first to seventh admissions, her serum creatinine levels remained normal. During her eighth hospitalization, her renal function deteriorated rapidly, culminating in renal crisis. Chest computed tomography (CT) confirmed pulmonary edema, necessitating hemodialysis. Her interleukin (IL)-6 level increased significantly during throughout hospitalizations. The patient responded well to treatment with an IL-6 receptor antagonist (IL-6RA). This case raises the question of whether IL-6 could serve as a potential biomarker for predicting renal crisis incidence in MCTD patients, a topic warranting further investigation in the future.
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来源期刊
European Journal of Inflammation
European Journal of Inflammation Medicine-Immunology and Allergy
自引率
0.00%
发文量
54
期刊介绍: European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.
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