{"title":"一名患有多灶性原发性（胸腹）神经母细胞瘤的 3 岁儿童--病例报告和文献综述","authors":"Ayesha Rahmat , Swaminathan Keerthivasagam , Sajid Qureshi , Puja Bathala , Mukta Ramadwar , Gramani Arumugam Vasugi , Harshavardhan Mahalingam , Vasundhara Patil , Dhaarani Jayaraman , Julius Xavier Scott","doi":"10.1016/j.phoj.2024.04.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Multifocal primary neuroblastoma in the non-infantile age group is rare, posing challenges in risk stratification and surgery.</p></div><div><h3>Case report</h3><p>A 3-year-old girl presented with an abdominal mass and elevated urinary vanillylmandelic acid (218 mg/l). Positron emission tomography - computed tomography showed fluorodeoxyglucose-avid masses in the left suprarenal and posterior mediastinum with regional paraortic nodes. A biopsy of the suprarenal and thoracic masses was suggestive of ganglioneuroblastoma and ganglioneuroma. She was stratified as an intermediate risk, with the bone marrow being uninvolved and non-amplified MYCN. Gross tumor resection was achieved at all the sites after 2 cycles of neoadjuvant chemotherapy. She received 2 more cycles of adjuvant chemotherapy and has been disease-free for 3 years.</p></div><div><h3>Conclusion</h3><p>Multifocal primaries in the non-infantile age group have favorable biological features and a good outcome.</p></div>","PeriodicalId":101004,"journal":{"name":"Pediatric Hematology Oncology Journal","volume":"9 3","pages":"Pages 151-154"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468124524000354/pdfft?md5=601f31c42fd8a6ff92f98dfc0db54ab9&pid=1-s2.0-S2468124524000354-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A 3-year-old child with multifocal (thoracoabdominal) primary neuroblastoma: A case report and literature review\",\"authors\":\"Ayesha Rahmat , Swaminathan Keerthivasagam , Sajid Qureshi , Puja Bathala , Mukta Ramadwar , Gramani Arumugam Vasugi , Harshavardhan Mahalingam , Vasundhara Patil , Dhaarani Jayaraman , Julius Xavier Scott\",\"doi\":\"10.1016/j.phoj.2024.04.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Multifocal primary neuroblastoma in the non-infantile age group is rare, posing challenges in risk stratification and surgery.</p></div><div><h3>Case report</h3><p>A 3-year-old girl presented with an abdominal mass and elevated urinary vanillylmandelic acid (218 mg/l). Positron emission tomography - computed tomography showed fluorodeoxyglucose-avid masses in the left suprarenal and posterior mediastinum with regional paraortic nodes. A biopsy of the suprarenal and thoracic masses was suggestive of ganglioneuroblastoma and ganglioneuroma. She was stratified as an intermediate risk, with the bone marrow being uninvolved and non-amplified MYCN. Gross tumor resection was achieved at all the sites after 2 cycles of neoadjuvant chemotherapy. She received 2 more cycles of adjuvant chemotherapy and has been disease-free for 3 years.</p></div><div><h3>Conclusion</h3><p>Multifocal primaries in the non-infantile age group have favorable biological features and a good outcome.</p></div>\",\"PeriodicalId\":101004,\"journal\":{\"name\":\"Pediatric Hematology Oncology Journal\",\"volume\":\"9 3\",\"pages\":\"Pages 151-154\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2468124524000354/pdfft?md5=601f31c42fd8a6ff92f98dfc0db54ab9&pid=1-s2.0-S2468124524000354-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Hematology Oncology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468124524000354\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Hematology Oncology Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468124524000354","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A 3-year-old child with multifocal (thoracoabdominal) primary neuroblastoma: A case report and literature review
Introduction
Multifocal primary neuroblastoma in the non-infantile age group is rare, posing challenges in risk stratification and surgery.
Case report
A 3-year-old girl presented with an abdominal mass and elevated urinary vanillylmandelic acid (218 mg/l). Positron emission tomography - computed tomography showed fluorodeoxyglucose-avid masses in the left suprarenal and posterior mediastinum with regional paraortic nodes. A biopsy of the suprarenal and thoracic masses was suggestive of ganglioneuroblastoma and ganglioneuroma. She was stratified as an intermediate risk, with the bone marrow being uninvolved and non-amplified MYCN. Gross tumor resection was achieved at all the sites after 2 cycles of neoadjuvant chemotherapy. She received 2 more cycles of adjuvant chemotherapy and has been disease-free for 3 years.
Conclusion
Multifocal primaries in the non-infantile age group have favorable biological features and a good outcome.
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