氧离子束在大鼠脊髓中的相对生物有效性:与线性能量传递和剂量的关系以及与模型预测的比较

IF 3.4 Q2 ONCOLOGY
Christin Glowa , Maria Saager , Lisa Hintz , Rosemarie Euler-Lange , Peter Peschke , Stephan Brons , Michael Scholz , Stewart Mein , Andrea Mairani , Christian P. Karger
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引用次数: 0

摘要

背景和目的与光子相比,离子束具有更高的相对生物有效性(RBE)。本研究测定了氧离子束在大鼠脊髓中的相对生物效应(RBE)与线性能量传递(LET)和剂量的函数关系。材料和方法在 6 厘米散开的布拉格峰(LET:26、66、98 和 141 keV/µm)的四个不同位置,使用不断增加的单个和分割氧离子剂量照射大鼠脊髓。结果当 LET 从 26 keV/µm 增加到 98 keV/µm 时,ED50 从 17.2 ± 0.3 Gy 下降到 13.2 ± 0.3 Gy。然而,在 141 keV/µm 时,ED50 又分别上升到 15.8 ± 0.4 Gy 和 17.2 ± 0.4 Gy。因此,RBE 分别从 1.43 ± 0.05 增加到 1.82 ± 0.08(单剂量)和从 1.58 ± 0.04 增加到 2.21 ± 0.08(分剂量),然后在最高 LET 下再次下降到单剂量的 1.56 ± 0.06 和分剂量的 1.99 ± 0.06。该研究首次建立了单剂量和分剂量氧离子作用于晚期反应中枢神经系统后的 RBE 数据。这些数据被用来验证三个 RBE 模型的 RBE 与 LET 和剂量的关系。这项研究扩展了质子、氦离子和碳离子的现有数据基础,为今后使用氧离子治疗病人提供了重要信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relative biological effectiveness of oxygen ion beams in the rat spinal cord: Dependence on linear energy transfer and dose and comparison with model predictions

Background and purpose

Ion beams exhibit an increased relative biological effectiveness (RBE) with respect to photons. This study determined the RBE of oxygen ion beams as a function of linear energy transfer (LET) and dose in the rat spinal cord.

Materials and methods

The spinal cord of rats was irradiated at four different positions of a 6 cm spread-out Bragg-peak (LET: 26, 66, 98 and 141 keV/µm) using increasing levels of single and split oxygen ion doses. Dose-response curves were established for the endpoint paresis grade II and based on ED50 (dose at 50 % effect probability), the RBE was determined and compared to model predictions.

Results

When LET increased from 26 to 98 keV/µm, ED50 decreased from 17.2 ± 0.3 Gy to 13.5 ± 0.4 Gy for single and from 21.7 ± 0.4 Gy to 15.5 ± 0.5 Gy for split doses, however, at 141 keV/µm, ED50 rose again to 15.8 ± 0.4 Gy and 17.2 ± 0.4 Gy, respectively. As a result, the RBE increased from 1.43 ± 0.05 to 1.82 ± 0.08 (single dose) and from 1.58 ± 0.04 to 2.21 ± 0.08 (split dose), respectively, before declining again to 1.56 ± 0.06 for single and 1.99 ± 0.06 for split doses at the highest LET. Deviations from RBE-predictions were model-dependent.

Conclusion

This study established first RBE data for the late reacting central nervous system after single and split doses of oxygen ions. The data was used to validate the RBE-dependence on LET and dose of three RBE-models. This study extends the existing data base for protons, helium and carbon ions and provides important information for future patient treatments with oxygen ions.

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来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
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