Agus Sulaeman, E. Susilawati, Marita Kaniawati, Irfan Mustofa, Yulvian Sani
{"title":"富含碳水化合物、脂肪和果糖的饮食对胰岛素抵抗发展的影响","authors":"Agus Sulaeman, E. Susilawati, Marita Kaniawati, Irfan Mustofa, Yulvian Sani","doi":"10.46542/pe.2024.242.121126","DOIUrl":null,"url":null,"abstract":"Background: Insulin resistance can be caused by carbohydrates, fats, and fructose. Insulin resistance is defined as a decrease in insulin's ability to stimulate the use of glucose for distribution to other parts of the body or a decrease in organ/cell response (fat tissue, liver, and muscle) to insulin.\nAim: The goal of this study is to see how different diets high in fat, carbohydrates, and fructose affect the incidence of insulin resistance.\nMethods: The study was conducted for 60 days and used 24 male white rats (Rattus norvegicus) Wistar strain aged two months with 180-200 grams body weight. They were divided into four groups, namely the normal group, the high-carbohydrate-fat (CF) diet group, the Carbohydrate-Fat-Fructose (CFF) and the Carbohydrate-fat-Fructose-Drink (CFFD) diet group. Blood glucose levels, the oral glucose tolerance test (ITT), and histological features of pancreatic beta cells were all measured.\nResults: The CFF group had the highest blood glucose level of 111.25 mg/dl and the highest insulin resistance with an ITT value of 2.81, while the CF group had pancreatic beta cell (β) necrosis.\nConclusion: According to the findings of this study, the CFF group had insulin resistance, while the CF group had pancreatic beta cell necrosis.","PeriodicalId":0,"journal":{"name":"","volume":"179 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of a diet rich in carbohydrates, fats, and fructose on insulin resistance development\",\"authors\":\"Agus Sulaeman, E. Susilawati, Marita Kaniawati, Irfan Mustofa, Yulvian Sani\",\"doi\":\"10.46542/pe.2024.242.121126\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Insulin resistance can be caused by carbohydrates, fats, and fructose. Insulin resistance is defined as a decrease in insulin's ability to stimulate the use of glucose for distribution to other parts of the body or a decrease in organ/cell response (fat tissue, liver, and muscle) to insulin.\\nAim: The goal of this study is to see how different diets high in fat, carbohydrates, and fructose affect the incidence of insulin resistance.\\nMethods: The study was conducted for 60 days and used 24 male white rats (Rattus norvegicus) Wistar strain aged two months with 180-200 grams body weight. They were divided into four groups, namely the normal group, the high-carbohydrate-fat (CF) diet group, the Carbohydrate-Fat-Fructose (CFF) and the Carbohydrate-fat-Fructose-Drink (CFFD) diet group. Blood glucose levels, the oral glucose tolerance test (ITT), and histological features of pancreatic beta cells were all measured.\\nResults: The CFF group had the highest blood glucose level of 111.25 mg/dl and the highest insulin resistance with an ITT value of 2.81, while the CF group had pancreatic beta cell (β) necrosis.\\nConclusion: According to the findings of this study, the CFF group had insulin resistance, while the CF group had pancreatic beta cell necrosis.\",\"PeriodicalId\":0,\"journal\":{\"name\":\"\",\"volume\":\"179 35\",\"pages\":\"\"},\"PeriodicalIF\":0.0,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46542/pe.2024.242.121126\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46542/pe.2024.242.121126","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of a diet rich in carbohydrates, fats, and fructose on insulin resistance development
Background: Insulin resistance can be caused by carbohydrates, fats, and fructose. Insulin resistance is defined as a decrease in insulin's ability to stimulate the use of glucose for distribution to other parts of the body or a decrease in organ/cell response (fat tissue, liver, and muscle) to insulin.
Aim: The goal of this study is to see how different diets high in fat, carbohydrates, and fructose affect the incidence of insulin resistance.
Methods: The study was conducted for 60 days and used 24 male white rats (Rattus norvegicus) Wistar strain aged two months with 180-200 grams body weight. They were divided into four groups, namely the normal group, the high-carbohydrate-fat (CF) diet group, the Carbohydrate-Fat-Fructose (CFF) and the Carbohydrate-fat-Fructose-Drink (CFFD) diet group. Blood glucose levels, the oral glucose tolerance test (ITT), and histological features of pancreatic beta cells were all measured.
Results: The CFF group had the highest blood glucose level of 111.25 mg/dl and the highest insulin resistance with an ITT value of 2.81, while the CF group had pancreatic beta cell (β) necrosis.
Conclusion: According to the findings of this study, the CFF group had insulin resistance, while the CF group had pancreatic beta cell necrosis.