富含碳水化合物、脂肪和果糖的饮食对胰岛素抵抗发展的影响

Pub Date : 2024-04-01 DOI:10.46542/pe.2024.242.121126
Agus Sulaeman, E. Susilawati, Marita Kaniawati, Irfan Mustofa, Yulvian Sani
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引用次数: 0

摘要

背景:胰岛素抵抗可由碳水化合物、脂肪和果糖引起。胰岛素抵抗的定义是:胰岛素刺激身体其他部位利用葡萄糖的能力下降,或器官/细胞(脂肪组织、肝脏和肌肉)对胰岛素的反应降低:研究为期 60 天,使用 24 只雄性白鼠(Rattus norvegicus)Wistar 品系,年龄为两个月,体重为 180-200 克。它们被分为四组,即正常组、高碳水化合物-脂肪(CF)饮食组、碳水化合物-脂肪-果糖(CFF)饮食组和碳水化合物-脂肪-果糖-饮料(CFFD)饮食组。对血糖水平、口服葡萄糖耐量试验(ITT)和胰腺β细胞的组织学特征进行了测量:结果:CFF 组血糖水平最高,为 111.25 mg/dl,胰岛素抵抗最高,ITT 值为 2.81,而 CF 组胰岛β细胞(β)坏死:本研究结果显示,CFF 组存在胰岛素抵抗,而 CF 组存在胰岛β细胞坏死。
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Impact of a diet rich in carbohydrates, fats, and fructose on insulin resistance development
Background: Insulin resistance can be caused by carbohydrates, fats, and fructose. Insulin resistance is defined as a decrease in insulin's ability to stimulate the use of glucose for distribution to other parts of the body or a decrease in organ/cell response (fat tissue, liver, and muscle) to insulin. Aim: The goal of this study is to see how different diets high in fat, carbohydrates, and fructose affect the incidence of insulin resistance. Methods: The study was conducted for 60 days and used 24 male white rats (Rattus norvegicus) Wistar strain aged two months with 180-200 grams body weight. They were divided into four groups, namely the normal group, the high-carbohydrate-fat (CF) diet group, the Carbohydrate-Fat-Fructose (CFF) and the Carbohydrate-fat-Fructose-Drink (CFFD) diet group. Blood glucose levels, the oral glucose tolerance test (ITT), and histological features of pancreatic beta cells were all measured. Results: The CFF group had the highest blood glucose level of 111.25 mg/dl and the highest insulin resistance with an ITT value of 2.81, while the CF group had pancreatic beta cell (β) necrosis. Conclusion: According to the findings of this study, the CFF group had insulin resistance, while the CF group had pancreatic beta cell necrosis.
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