Nariman Mokhaberi, Michalis Aftzoglou, Philipp Schneider, Daniel Biermann, Rainer Gerhard Kozlik-Feldmann, Christian Tomuschat, Christine Drießler, Armin-Johannes Michel, Andrea Schmedding, Florentine Weise, Niklas Dressler, N. Peukert, Johannes Düß, S. Mayer, M. Lacher, Jan Riedel, Yuqing Lu, Julia Elrod, S. Turial, Maciej Pech, Volker Aumann, A. Nyiredi, Lena Bode, Jan-Hendrik Gosemann, Gabriel Götz, Robin Wachowiak, Peter Zimmermann, Tomasz Baranski, Matthias Nissen, Ralf-Bodo Tröbs, I. Martynov, Monika Sparber-Sauer, Amadeus T Heinz, C. Vokuhl, Martin Ebinger, J. Gesche, Marc Münter, E. Koscielniak, Jörg Fuchs, Guido Seitz, Mark Schneider, Ruben Visschers, U. Kontny, Ulf Neumann, Wilhelmus van Gemert
{"title":"摘要 DGKCH","authors":"Nariman Mokhaberi, Michalis Aftzoglou, Philipp Schneider, Daniel Biermann, Rainer Gerhard Kozlik-Feldmann, Christian Tomuschat, Christine Drießler, Armin-Johannes Michel, Andrea Schmedding, Florentine Weise, Niklas Dressler, N. Peukert, Johannes Düß, S. Mayer, M. Lacher, Jan Riedel, Yuqing Lu, Julia Elrod, S. Turial, Maciej Pech, Volker Aumann, A. Nyiredi, Lena Bode, Jan-Hendrik Gosemann, Gabriel Götz, Robin Wachowiak, Peter Zimmermann, Tomasz Baranski, Matthias Nissen, Ralf-Bodo Tröbs, I. Martynov, Monika Sparber-Sauer, Amadeus T Heinz, C. Vokuhl, Martin Ebinger, J. Gesche, Marc Münter, E. Koscielniak, Jörg Fuchs, Guido Seitz, Mark Schneider, Ruben Visschers, U. Kontny, Ulf Neumann, Wilhelmus van Gemert","doi":"10.1515/iss-2024-2005","DOIUrl":null,"url":null,"abstract":"Impaired intestinal endotoxin tolerance is seen in human preterms suffering from necrotizing enterocolitis (NEC), but the underlying mechanism remains unknown. Activation of the TLR4/p65 pathway deregulates β-catenin abundance in intestinal epithelial cells (IECs) from human NEC patients. The cell adhesion molecule β-catenin plays a crucial role in transcriptional activation of proliferation and cell growth in intestinal epithelial cells (IECs). It has been shown that β-catenin acts either as a pro-or anti-inflammatory mediator in a cell and tissue specific behavior. This study aims to elucidate the effects of stabilized β-catenin upon lipopolysaccharide (LPS) induced inflammatory signaling in IECs.","PeriodicalId":44186,"journal":{"name":"Innovative Surgical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Abstracts DGKCH\",\"authors\":\"Nariman Mokhaberi, Michalis Aftzoglou, Philipp Schneider, Daniel Biermann, Rainer Gerhard Kozlik-Feldmann, Christian Tomuschat, Christine Drießler, Armin-Johannes Michel, Andrea Schmedding, Florentine Weise, Niklas Dressler, N. Peukert, Johannes Düß, S. Mayer, M. Lacher, Jan Riedel, Yuqing Lu, Julia Elrod, S. Turial, Maciej Pech, Volker Aumann, A. Nyiredi, Lena Bode, Jan-Hendrik Gosemann, Gabriel Götz, Robin Wachowiak, Peter Zimmermann, Tomasz Baranski, Matthias Nissen, Ralf-Bodo Tröbs, I. Martynov, Monika Sparber-Sauer, Amadeus T Heinz, C. Vokuhl, Martin Ebinger, J. Gesche, Marc Münter, E. Koscielniak, Jörg Fuchs, Guido Seitz, Mark Schneider, Ruben Visschers, U. Kontny, Ulf Neumann, Wilhelmus van Gemert\",\"doi\":\"10.1515/iss-2024-2005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Impaired intestinal endotoxin tolerance is seen in human preterms suffering from necrotizing enterocolitis (NEC), but the underlying mechanism remains unknown. Activation of the TLR4/p65 pathway deregulates β-catenin abundance in intestinal epithelial cells (IECs) from human NEC patients. The cell adhesion molecule β-catenin plays a crucial role in transcriptional activation of proliferation and cell growth in intestinal epithelial cells (IECs). It has been shown that β-catenin acts either as a pro-or anti-inflammatory mediator in a cell and tissue specific behavior. This study aims to elucidate the effects of stabilized β-catenin upon lipopolysaccharide (LPS) induced inflammatory signaling in IECs.\",\"PeriodicalId\":44186,\"journal\":{\"name\":\"Innovative Surgical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Innovative Surgical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/iss-2024-2005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Innovative Surgical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/iss-2024-2005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Impaired intestinal endotoxin tolerance is seen in human preterms suffering from necrotizing enterocolitis (NEC), but the underlying mechanism remains unknown. Activation of the TLR4/p65 pathway deregulates β-catenin abundance in intestinal epithelial cells (IECs) from human NEC patients. The cell adhesion molecule β-catenin plays a crucial role in transcriptional activation of proliferation and cell growth in intestinal epithelial cells (IECs). It has been shown that β-catenin acts either as a pro-or anti-inflammatory mediator in a cell and tissue specific behavior. This study aims to elucidate the effects of stabilized β-catenin upon lipopolysaccharide (LPS) induced inflammatory signaling in IECs.
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