口腔薄膜概述--方法、表征和当前方法

Ruchita Badekar, Vishal Bodke, Bharat W. Tekade, Swapnil D. Phalak
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引用次数: 0

摘要

制药行业正在寻找新的给药方式,其中一种方式就是薄膜。有人说,薄膜是传统剂型的替代品。它们能迅速产生局部或全身效应,是一种非常灵活的平台。此外,有吞咽困难的病人、老人、儿科病人、卧床不起的病人,以及取水有困难的病人,都可以很容易地自行使用这些系统。这些给药系统有多种给药方式,包括经皮、眼部、口腔、舌下和口服。目前,全球众多制药公司和学术专家正在研究这些薄膜在输送合成和天然药物方面的潜力。这种特殊给药方法的妙处在于,我们可以从受试者服用传统剂型(片剂、胶囊)的情况中看到,它们不需要水就可以服用。本综述详细回顾了口服薄膜的应用和制备方法;本研究的重点是向研究人员介绍薄膜,以及过去 10 年薄膜与药物和研究中使用的聚合物的研究情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
AN OVERVIEW ON ORAL THIN FILMS–METHODOLOGY, CHARACTERIZATION AND CURRENT APPROACH
The pharmaceutical sector is looking for new ways to deliver drugs, and one such way is through thin films. It has been said that thin films offer an alternative to traditional dosage forms. They offer rapid, local, or systemic effects and are a very flexible platform. Furthermore, patients with dysphagia, elderly, paediatrics, or bedridden patients, as well as those who have difficulty accessing water, can easily utilize these systems on their own. There are several ways to administer these drug delivery systems, including transdermally, ocularly, buccally, sublingually, and orally. One of the most creative and patient-focused novel drug delivery systems is Orodispersible Thin Films (OTF). Numerous pharmaceutical companies and academic experts worldwide are currently investigating the potential of these films for delivering drugs derived from both synthetic and natural sources. The beauty of this special drug delivery method is that, as we can see from the subjects' consumption of conventional dosage forms (tablets, capsules), they don't require water to be consumed. Furthermore, these delivery methods do a great job of encouraging patient compliance in general, especially in the case of both older and pediatric patients. This review shows a detailed review of oral thin film its applications and method of preparation; mainly focus of this research is thin film introduction to researchers and last 10 y of research on thin film with drugs and polymers used in research.
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