{"title":"T2DM 患者血清维生素 E 与 HOMA-IR 之间的相关性","authors":"Jing Zhang, Yilin Hou, Zhaozi Zhang, Yihe Shi, Zhimin Wang, Guangyao Song","doi":"10.2147/dmso.s450738","DOIUrl":null,"url":null,"abstract":"Background: Peroxidation is one of the important causes of insulin resistance (IR), and vitamin E is a natural antioxidant, and there may be some correlation between serum vitamin E levels and insulin resistance. Purpose: The correlation between serum vitamin E and insulin resistance in type 2 diabetes mellitus (T2DM) population. Methods: Two hundred and forty-two people (119 with T2DM) were included. One hundred and nineteen patients with T2DM were selected as the case group, and 123 people with non-T2DM were selected as the control group. People insulin resistance was detected by the homeostasis model assessment method (HOMA-IR) greater than 2.69 were included in the diabetic insulin resistance group, and those with HOMA-IR less than 2.69 were included in the diabetic non-insulin resistance group. Record the general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Correlation analysis, logistic regression, trend analysis, and restricted cubic spline (RCS) were performed using SPSS 25.0 and R 4.1.1 software. Correlation analysis, logistic regression, trend analysis, restricted cubic spline (RCS) analysis were conducted on general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Results: The logistic regression results showed that after adjusting for confounding factors, vitamin E was an independent influencing factor for insulin resistance in T2DM patients (P < 0.001). The trend analysis results show that with the decrease of serum vitamin E levels, the risk of insulin resistance in T2DM patients gradually increases. The RCS results showed that the risk of insulin resistance was significantly increased when the serum vitamin E level was lower than 10,575.23 ng/mL. Conclusion: Serum vitamin E levels are lower in T2DM patients than in healthy populations; Vitamin E is an independent influencing factor for HOMA-IR in T2DM patients. The risk of insulin resistance gradually increases in T2DM patients as serum vitamin E levels decrease. Vitamin E is a risk factor for insulin resistance at serum vitamin E levels below 10,575.23 ng/mL. At higher serum vitamin E levels than 10,575.23 ng/mL, vitamin E is a protective factor for insulin resistance.","PeriodicalId":504951,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity","volume":"67 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlation Between Serum Vitamin E and HOMA-IR in Patients with T2DM\",\"authors\":\"Jing Zhang, Yilin Hou, Zhaozi Zhang, Yihe Shi, Zhimin Wang, Guangyao Song\",\"doi\":\"10.2147/dmso.s450738\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Peroxidation is one of the important causes of insulin resistance (IR), and vitamin E is a natural antioxidant, and there may be some correlation between serum vitamin E levels and insulin resistance. Purpose: The correlation between serum vitamin E and insulin resistance in type 2 diabetes mellitus (T2DM) population. Methods: Two hundred and forty-two people (119 with T2DM) were included. One hundred and nineteen patients with T2DM were selected as the case group, and 123 people with non-T2DM were selected as the control group. People insulin resistance was detected by the homeostasis model assessment method (HOMA-IR) greater than 2.69 were included in the diabetic insulin resistance group, and those with HOMA-IR less than 2.69 were included in the diabetic non-insulin resistance group. Record the general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Correlation analysis, logistic regression, trend analysis, and restricted cubic spline (RCS) were performed using SPSS 25.0 and R 4.1.1 software. Correlation analysis, logistic regression, trend analysis, restricted cubic spline (RCS) analysis were conducted on general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Results: The logistic regression results showed that after adjusting for confounding factors, vitamin E was an independent influencing factor for insulin resistance in T2DM patients (P < 0.001). The trend analysis results show that with the decrease of serum vitamin E levels, the risk of insulin resistance in T2DM patients gradually increases. The RCS results showed that the risk of insulin resistance was significantly increased when the serum vitamin E level was lower than 10,575.23 ng/mL. Conclusion: Serum vitamin E levels are lower in T2DM patients than in healthy populations; Vitamin E is an independent influencing factor for HOMA-IR in T2DM patients. The risk of insulin resistance gradually increases in T2DM patients as serum vitamin E levels decrease. Vitamin E is a risk factor for insulin resistance at serum vitamin E levels below 10,575.23 ng/mL. At higher serum vitamin E levels than 10,575.23 ng/mL, vitamin E is a protective factor for insulin resistance.\",\"PeriodicalId\":504951,\"journal\":{\"name\":\"Diabetes, Metabolic Syndrome and Obesity\",\"volume\":\"67 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes, Metabolic Syndrome and Obesity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/dmso.s450738\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Metabolic Syndrome and Obesity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/dmso.s450738","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景：过氧化是导致胰岛素抵抗（IR）的重要原因之一，而维生素 E 是一种天然抗氧化剂，血清维生素 E 水平与胰岛素抵抗之间可能存在一定的相关性。目的：研究 2 型糖尿病（T2DM）人群血清维生素 E 与胰岛素抵抗之间的相关性。方法纳入 242 人（其中 119 人患有 T2DM）。选择 119 名 T2DM 患者为病例组，123 名非 T2DM 患者为对照组。用稳态模型评估法（HOMA-IR）检测出胰岛素抵抗大于 2.69 者为糖尿病胰岛素抵抗组，HOMA-IR 小于 2.69 者为糖尿病非胰岛素抵抗组。记录全身指标、生化指标、肝功能指标、维生素 E 等指标。使用 SPSS 25.0 和 R 4.1.1 软件进行相关分析、逻辑回归、趋势分析和受限立方样条曲线（RCS）分析。对全身指标、生化指标、肝功能指标、维生素 E 和其他指标进行了相关分析、逻辑回归分析、趋势分析和限制性三次样条（RCS）分析。结果显示逻辑回归结果显示，调整混杂因素后，维生素 E 是 T2DM 患者胰岛素抵抗的独立影响因素（P < 0.001）。趋势分析结果显示，随着血清维生素 E 水平的降低，T2DM 患者发生胰岛素抵抗的风险逐渐增加。RCS 结果显示，当血清维生素 E 水平低于 10,575.23 纳克/毫升时，胰岛素抵抗的风险显著增加。结论T2DM 患者的血清维生素 E 水平低于健康人群；维生素 E 是 T2DM 患者 HOMA-IR 的独立影响因素。随着血清维生素 E 水平的降低，T2DM 患者出现胰岛素抵抗的风险逐渐增加。当血清维生素 E 水平低于 10,575.23 纳克/毫升时，维生素 E 是胰岛素抵抗的危险因素。当血清维生素 E 水平高于 10,575.23 纳克/毫升时，维生素 E 是胰岛素抵抗的保护因素。
Correlation Between Serum Vitamin E and HOMA-IR in Patients with T2DM
Background: Peroxidation is one of the important causes of insulin resistance (IR), and vitamin E is a natural antioxidant, and there may be some correlation between serum vitamin E levels and insulin resistance. Purpose: The correlation between serum vitamin E and insulin resistance in type 2 diabetes mellitus (T2DM) population. Methods: Two hundred and forty-two people (119 with T2DM) were included. One hundred and nineteen patients with T2DM were selected as the case group, and 123 people with non-T2DM were selected as the control group. People insulin resistance was detected by the homeostasis model assessment method (HOMA-IR) greater than 2.69 were included in the diabetic insulin resistance group, and those with HOMA-IR less than 2.69 were included in the diabetic non-insulin resistance group. Record the general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Correlation analysis, logistic regression, trend analysis, and restricted cubic spline (RCS) were performed using SPSS 25.0 and R 4.1.1 software. Correlation analysis, logistic regression, trend analysis, restricted cubic spline (RCS) analysis were conducted on general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Results: The logistic regression results showed that after adjusting for confounding factors, vitamin E was an independent influencing factor for insulin resistance in T2DM patients (P < 0.001). The trend analysis results show that with the decrease of serum vitamin E levels, the risk of insulin resistance in T2DM patients gradually increases. The RCS results showed that the risk of insulin resistance was significantly increased when the serum vitamin E level was lower than 10,575.23 ng/mL. Conclusion: Serum vitamin E levels are lower in T2DM patients than in healthy populations; Vitamin E is an independent influencing factor for HOMA-IR in T2DM patients. The risk of insulin resistance gradually increases in T2DM patients as serum vitamin E levels decrease. Vitamin E is a risk factor for insulin resistance at serum vitamin E levels below 10,575.23 ng/mL. At higher serum vitamin E levels than 10,575.23 ng/mL, vitamin E is a protective factor for insulin resistance.
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