线粒体对肿瘤放射性电阻率的影响机制

Q4 Medicine
J.M. Rozenberg, V.V. Maximov, D.V. Kuzmin, S.V. Leonov
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引用次数: 0

摘要

放疗仍然是治疗癌症的主要方法之一。与此同时,癌细胞对电离辐射形成的放射抗性(RR)会导致治疗效果下降。放疗的毒性由线粒体决定,而线粒体或其成分与化疗、放疗和免疫疗法结合使用可提高疗效。在这篇综述中,我们回顾了将线粒体用于癌症治疗的新实验方法。文献数据表明,虽然线粒体的生理性转运会促进癌变和对化疗的抵抗,但相反,移植外源性线粒体却能诱导小鼠癌症模型的放射敏感性并抑制肿瘤生长。因此,抑制癌症线粒体的内源性转运或开发外源性线粒体输送方法是抗癌药物开发的一个前景广阔的领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms of Mitochondrial Influence on Tumor Radioresistivity
Radiotherapy remains one of the main methods of cancer treatment. At the same time, the formation of radioresistance (RR)of cancer cells to ionizing radiation leads to a loss of therapy effectiveness. The toxicity of radiotherapy is determined by mitochondria, and the use of mitochondria or their components in combination with chemo-radio and immunotherapy can increase the effectiveness of treatment. In this review, we have reviewed new, experimental methods for using mitochondria in cancer therapy. Literature data indicate that although the physiological transport of mitochondria promotes carcinogenesis and resistance to chemotherapy, transplantation of exogenous mitochondria, on the contrary, induces radiosensitivity and inhibits tumor growth in mouse models of cancer. Therefore, inhibition of endogenous transfer of cancer mitochondria or the development of methods for the delivery of exogenous mitochondria is a promising area for the development of anti-cancer drugs.
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来源期刊
Medical Radiology and Radiation Safety
Medical Radiology and Radiation Safety Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.40
自引率
0.00%
发文量
72
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