miRNA 在大脑发育中的作用。

Himanshu Sharma, Monika Kaushik, Priyanka Goswami, Sanakattula Sreevani, Ananya Chakraborty, Sumel Ashique, Radheshyam Pal
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引用次数: 0

摘要

被称为微小核糖核酸(miRNA)的非编码核糖核酸体积很小,在转录后能中和基因的活动。神经系统是一个巨大的受压器官,越来越多的研究揭示了 miRNA 在大脑生长和神经活动中的重要功能。目前,miRNAs 对中枢神经系统发育的重大益处已通过新的科学方法显现出来,这些方法集中于靶向和消除重要的 miRNA 生物生成途径,其中包括 Dicer 和 DGCR8。miRNA 的调节与神经祖细胞的许多重要细胞过程有关,如分化、增殖和命运决定。本书收录的最新研究发现强调了 miRNA 在复杂的大脑发育过程中的重要作用。miRNA 通路在大脑发育、运行动态甚至疾病中发挥着重要作用。最近关于 miRNA 介导的神经差异、昼夜节律和突触重塑中的基因调控的研究就表明了这一点。我们还讨论了这些发现如何影响我们对大脑疾病背后基本过程的理解,并强调了 miRNA 为治疗各种人类疾病提供的新的治疗机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of miRNAs in Brain Development.
Non-coding RNAs that are small in size, called microRNAs (miRNAs), exert a conse-quence in neutralizing gene activity after transcription. The nervous system is a massively ex-pressed organ, and an expanding body of research reveals the vital functions that miRNAs play in the brain's growth and neural activity. The significant benefit of miRNAs on the development of the central nervous system is currently shown through new scientific methods that concentrate on targeting and eradicating vital miRNA biogenesis pathways the elements involving Dicer and DGCR8. Modulation of miRNA has been associated with numerous essential cellular processes on neural progenitors, like differentiation, proliferation, and destiny determination. Current re-search discoveries that emphasize the significance of miRNAs in the complex process of brain development are included in this book. The miRNA pathway plays a major role in brain devel-opment, its operational dynamics, and even diseases. Recent studies on miRNA-mediated gene regulation within neural discrepancy, the circadian period and synaptic remodeling are signs of this. We also discussed how these discoveries may affect our comprehension of the fundamental processes behind brain diseases, highlighting the novel therapeutic opportunities miRNAs pro-vide for treating various human illnesses.
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