他汀类药物治疗 3 个月后血清中副氧合酶(PON1)活性与血脂指标浓度的比较分析

Sharmistha Chatterjee, Biswajit Majumder, Prajwal Kumar Sinha, Indranil Chakraborty
{"title":"他汀类药物治疗 3 个月后血清中副氧合酶(PON1)活性与血脂指标浓度的比较分析","authors":"Sharmistha Chatterjee, Biswajit Majumder, Prajwal Kumar Sinha, Indranil Chakraborty","doi":"10.37506/hm9qbz10","DOIUrl":null,"url":null,"abstract":"Background: Human serum paraoxonase (PON1) residing on HDL can prevent the oxidation of low densitylipoprotein (LDL), the initiating factor in atherosclerosis. Statins are commonly used to treat dyslipidemia,aknown risk factor for coronary artery disease (CAD).The aim of the studyis to evaluate the alterations in theconcentrationof PON1 along with that of other parameters of lipid profile in patients of CAD before and after 3 months of statin therapy.Materials and Methods: The study included 30 new patients who were put on statin therapy following thediagnosis of acute coronary syndrome. The activity of PON1 (units-IU/L) and the concentration of lipid profileparameters (units-mg/dl) were estimated before starting statin therapy and again after three months. Patients with co-morbidities like diabetes, kidney disease, liver disease and other cardiac diseases of infectious aetiology were excluded.Results and Analysis: As expected, both PON1 and HDL have increased after 3 months. There was a statistically significant increase in both PON1 (p<0.05)and HDL (p<0.001) and a decrease (p <0.05, also statistically significant)in LDL after 3 months of statin therapy.Conclusion: This knowledge may be exploited in the follow up CAD patients. The increase in PONI and thesimilar increase in HDL after 3 months of statin therapy may be exploited in the follow-up of cardiac patients.","PeriodicalId":302882,"journal":{"name":"Indian Journal of Public Health Research &amp; Development","volume":"151 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Comparative Analysis of the Serum Paraoxonase (PON1) Activity and the Concentration of Parameters of Lipid Profile after 3 Months of Statin Therapy\",\"authors\":\"Sharmistha Chatterjee, Biswajit Majumder, Prajwal Kumar Sinha, Indranil Chakraborty\",\"doi\":\"10.37506/hm9qbz10\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Human serum paraoxonase (PON1) residing on HDL can prevent the oxidation of low densitylipoprotein (LDL), the initiating factor in atherosclerosis. Statins are commonly used to treat dyslipidemia,aknown risk factor for coronary artery disease (CAD).The aim of the studyis to evaluate the alterations in theconcentrationof PON1 along with that of other parameters of lipid profile in patients of CAD before and after 3 months of statin therapy.Materials and Methods: The study included 30 new patients who were put on statin therapy following thediagnosis of acute coronary syndrome. The activity of PON1 (units-IU/L) and the concentration of lipid profileparameters (units-mg/dl) were estimated before starting statin therapy and again after three months. Patients with co-morbidities like diabetes, kidney disease, liver disease and other cardiac diseases of infectious aetiology were excluded.Results and Analysis: As expected, both PON1 and HDL have increased after 3 months. There was a statistically significant increase in both PON1 (p<0.05)and HDL (p<0.001) and a decrease (p <0.05, also statistically significant)in LDL after 3 months of statin therapy.Conclusion: This knowledge may be exploited in the follow up CAD patients. The increase in PONI and thesimilar increase in HDL after 3 months of statin therapy may be exploited in the follow-up of cardiac patients.\",\"PeriodicalId\":302882,\"journal\":{\"name\":\"Indian Journal of Public Health Research &amp; Development\",\"volume\":\"151 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Public Health Research &amp; Development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37506/hm9qbz10\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Public Health Research &amp; Development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37506/hm9qbz10","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:驻留在高密度脂蛋白上的人血清副氧合酶(PON1)可以阻止低密度脂蛋白(LDL)的氧化,而低密度脂蛋白是动脉粥样硬化的起始因素。他汀类药物是治疗血脂异常的常用药物,而血脂异常是冠状动脉疾病(CAD)的一个已知风险因素。本研究的目的是评估他汀类药物治疗 3 个月前后,CAD 患者体内 PON1 浓度以及其他血脂指标的变化情况:研究对象包括 30 名诊断为急性冠状动脉综合征后接受他汀类药物治疗的新患者。在开始他汀类药物治疗前和三个月后,分别测定了 PON1 的活性(单位-IU/L)和血脂指标的浓度(单位-mg/dl)。排除了合并糖尿病、肾病、肝病和其他感染性心脏病的患者:不出所料,PON1 和 HDL 在 3 个月后均有所上升。他汀类药物治疗 3 个月后,PON1(P<0.05)和 HDL(P<0.001)均有统计学意义的增加,而 LDL 则有所下降(P<0.05,也有统计学意义):结论:这一知识可用于对 CAD 患者的随访。他汀类药物治疗 3 个月后,PONI 增加,高密度脂蛋白也同样增加,这一点可在心脏病患者的随访中加以利用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparative Analysis of the Serum Paraoxonase (PON1) Activity and the Concentration of Parameters of Lipid Profile after 3 Months of Statin Therapy
Background: Human serum paraoxonase (PON1) residing on HDL can prevent the oxidation of low densitylipoprotein (LDL), the initiating factor in atherosclerosis. Statins are commonly used to treat dyslipidemia,aknown risk factor for coronary artery disease (CAD).The aim of the studyis to evaluate the alterations in theconcentrationof PON1 along with that of other parameters of lipid profile in patients of CAD before and after 3 months of statin therapy.Materials and Methods: The study included 30 new patients who were put on statin therapy following thediagnosis of acute coronary syndrome. The activity of PON1 (units-IU/L) and the concentration of lipid profileparameters (units-mg/dl) were estimated before starting statin therapy and again after three months. Patients with co-morbidities like diabetes, kidney disease, liver disease and other cardiac diseases of infectious aetiology were excluded.Results and Analysis: As expected, both PON1 and HDL have increased after 3 months. There was a statistically significant increase in both PON1 (p<0.05)and HDL (p<0.001) and a decrease (p <0.05, also statistically significant)in LDL after 3 months of statin therapy.Conclusion: This knowledge may be exploited in the follow up CAD patients. The increase in PONI and thesimilar increase in HDL after 3 months of statin therapy may be exploited in the follow-up of cardiac patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信