美尼兰叶提取物对肉鸡新城疫抗体滴度的潜在影响

Buletin Veteriner Udayana Pub Date : 2024-04-05 DOI:10.24843/bulvet.2024.v16.i02.p15

Citra Widiawati, Ida Bagus Kade Suardana, G. A. Y. Kencana, N. L. E. Setiasih, T. S. Nindhia, A. A. S. Kendran

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引用次数: 0

摘要

新城疫（ND）是容易侵袭肉鸡的传染病之一。为提高鸡的免疫力而进行的疫苗接种往往效果不佳，因此需要绿膜兰（Phyllanthus niruri Linn.）作为免疫增强剂。绿毛番荔枝叶提取物的主要成分是黄酮类化合物，可触发 T 细胞帮助 B 细胞产生抗体。本研究旨在确定青钱柳叶提取物（Phyllanthus niruri Linn.）对加强免疫肉鸡 ND 抗体滴度的影响。研究设计采用了完全随机设计的嵌套模式，共有 30 只肉鸡被分为三个处理组，即 10 只肉鸡未接种玖玖拉索塔加强免疫疫苗，也未接种月桂叶提取物，但接种了安慰剂（K-）；10 只肉鸡接种了玖玖拉索塔加强免疫疫苗，但未接种月桂叶提取物（K+）；10 只肉鸡接种了玖玖拉索塔加强免疫疫苗，并在接种前 7 天和接种后 14 天在饮用水中添加了月桂叶提取物（P）。使用的样本分别为加强免疫前一天（9 日龄肉鸡）、加强免疫后一周（17 日龄肉鸡）和加强免疫后两周（24 日龄肉鸡）。获得的血清通过血凝抑制（HI）试验进行血清学检验。获得的数据使用 SPSS（统计产品和服务解决方案）软件进行统计分析（显著性水平为 5%）和回归分析。结果表明，在接种 ND 加强免疫后施用 meniran 叶提取物（Phyllanthus niruri Linn.）和取样时间的影响会增加 ND 抗体滴度，P 处理的平均值为 2.8、4.3、7.1，总平均值为 4.7（滴度以 HI log 2 表示），差异显著（P < 0.05）。回归分析表明，与 K- 和 K+ 处理相比，P 处理在 ND 强毒疫苗接种后第三周的抗体滴度增幅最大。

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POTENTIAL OF MENIRAN LEAF EXTRACT ON NEWCASTLE DISEASE ANTIBODY TITER IN BROILERS

Newcastle Disease (ND) is one of the infectious diseases that easily attack broilers. Vaccinations carried out to optimize chicken immunity often get unsatisfactory results, so green meniran (Phyllanthus niruri Linn.) is needed as an immunostimulator. Green meniran leaf extract contains flavonoid compounds as the main component to trigger T cells to help B cells to produce antibodies. This study aims to determine the effect of meniran leaf extract (Phyllanthus niruri Linn.) on booster vaccinated broilers on ND antibody titer. The research design used was a complete randomized design in a nested pattern with a total of 30 broilers divided into three treatment groups, namely 10 broilers not given the ND La Sota booster vaccine and not given meniran leaf extract but given a placebo (K-), 10 broilers given the ND La Sota booster vaccine without meniran leaf extract (K+), and 10 broilers given the ND La Sota booster vaccine and meniran leaf extract in drinking water for seven days before and 14 days after vaccination (P). The samples used were one day before booster vaccination (9-day-old broilers), one week after booster vaccination (17-day-old broilers) and two weeks after booster vaccination (24-day-old broilers). Serum obtained was examined serologically by hemagglutination inhibition (HI) test. The data obtained were analyzed statistically Analysis of Variance (Anova) with a significant level of 5% and regression analysis using SPSS (Statistical Product and Service Solution) software. The results showed that in the administration of meniran leaf extract(Phyllanthus niruri Linn.) and the effect of sampling time after ND booster vaccination had an increase in ND antibody titer which was significantly different (P < 0.05) in treatment P with a mean of 2.8; 4.3; 7.1 and a total mean of 4.7 (titer in HI log 2). Regression analysis showed that the P treatment had the highest increase in the third week after ND booster vaccination compared to the K- and K+ treatments.

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Buletin Veteriner Udayana

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8 weeks