AP-1 适配复合物在传出和传入膜交通中的作用

The Journal of Cell Biology Pub Date : 2024-04-05 DOI:10.1083/jcb.202310071

M. S. Robinson, Robin Antrobus, Anneri Sanger, A. Davies, David C. Gershlick

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引用次数: 0

摘要

Robinson 等人在共表达标记 AP-1 和货物蛋白的细胞上使用互补方法研究了 AP-1 的功能。他们的研究结果支持这样一个模型：AP-1 被招募到后高尔基体载体和早期/循环内体上，并在那里将选定的蛋白质检索回 TGN。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic

Robinson et al. investigate AP-1 function using complementary approaches on cells coexpressing tagged AP-1 and cargo proteins. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes, where it retrieves selected proteins back to the TGN.

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来源期刊

The Journal of Cell Biology

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