舒利迭治疗癫痫的疗效和耐受性:文献综述

K. Mukhin, O. Pylaeva, А. V. Мarkin
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引用次数: 0

摘要

本综述旨在总结舒思安坦对不同形式癫痫的疗效和耐受性方面的现有证据。对国际刊物的分析表明,舒思安被认为是治疗伴有中央颞区棘波的年龄依赖性癫痫(罗兰性癫痫)的一线药物。舒思安对睡眠时表现为尖波活动的癫痫性脑病(包括朗道-克莱夫纳综合征)患儿以及肌阵挛性发作患者非常有效。这种药物对其他形式的局灶性癫痫患者也可能有效,包括对治疗产生抗药性的患者。与旧的抗癫痫药物甚至左乙拉西坦相比,舒利迭的耐受性更高,因此因不良反应而中断治疗的风险较低。此外,舒思安还可用于治疗行为障碍(如多动行为、攻击性)和认知障碍。舒眠宁对癫痫和睡眠呼吸暂停患者有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and tolerability of sulthiame in the treatment of epilepsy: a literature review
This review aims to summarize the available evidence on the efficacy and tolerability of sulthiame for different forms of epilepsy. The analysis of international publications suggests that sulthiame is considered as a first-line drug for the treatment of age-dependent epilepsy with central temporal spikes (rolandic epilepsy). Sulthiame is highly effective in children with epileptic encephalopathies manifesting with spike-and-wave activity during sleep, including Landau-Kleffner syndrome, as well as in patients with myoclonic seizures. The drug might be also effective in patients with other forms of focal epilepsy, including those resistant to therapy. The tolerability of sulthiame is higher that that of old antiepileptic drugs and even levetiracetam; thus, it is associated with a lower risk of treatment interruptions due to adverse events. Moreover, sulthiame can be used for behavioral disorders (such as hyperkinetic behavior, aggressiveness) and cognitive impairments. Sulthiame can be effective in patients with epilepsy and sleep apnea.
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