软组织肉瘤微环境的组成部分。第一部分

A. Lokhonina, E. Jumaniyazova, D. Dzhalilova, A. Kosyreva, G. G. Kazaryan, T. Fatkhudinov
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引用次数: 0

摘要

软组织肉瘤(STS)是一种罕见的异质性恶性肿瘤,其特点是病程凶险、治疗反应差。这就决定了研究软组织肉瘤发病机制的重要性。肿瘤微环境由基质、免疫细胞、血液、淋巴管和细胞外基质组成。目前已知,STS 的特点是肿瘤细胞与微环境成分之间关系复杂。肿瘤细胞与微环境成分之间的动态相互作用增强了对不断变化的环境条件的适应性,从而使 STS 具有很高的侵袭潜力,并对抗肿瘤治疗产生抗药性。旨在研究微环境成分在 STS 癌变中的作用的基础研究可能是发现新的预后预测生物标志物和新的抗肿瘤药物靶点的关键。这篇综述文章将专门讨论 STS 细胞与微环境成分的作用和相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Components of the microenvironment of soft tissue sarcomas. Part I
Soft tissue sarcomas (STS) are a rare heterogeneous group of malignant neoplasms characterized by aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STS. The tumor microenvironment consists of stromal, immune cells, blood, lymphatic vessels, and extracellular matrix. By now, it is known that STS is characterized by complex relationships between tumor cells and components of the microenvironment. Dynamic interactions between tumor cells and components of the microenvironment enhance adaptation to changing environmental conditions, which provides high aggressive potential of STS and resistance to antitumor therapy. Basic research aimed at investigating the role of microenvironmental components in STS carcinogenesis may serve as a key to the discovery of both new prognostic predictor biomarkers and targets for new antitumor drugs. This review article is devoted to the role and interaction of STS cells with components of the microenvironment.
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