Melipona beecheii 蜜蜂所产蜂蜜的体内伤口愈合和抗炎活性

IF 1 Q4 PHARMACOLOGY & PHARMACY
Ina Ramírez Miranda, J. Acevedo-Fernández, Elizabeth Negrete-León, David Abram Betancur-Ancona, Yolanda Beatriz Moguel-Ordoñez
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引用次数: 0

摘要

背景:Melipona beecheii 蜜蜂酿造的蜂蜜因其治疗功效,尤其是在伤口愈合方面的功效,自西班牙前时期以来就在墨西哥备受推崇。研究目的本研究旨在利用动物模型评估 Melipona beecheii 蜂蜜的体内伤口愈合和抗炎作用。方法:蜂蜜样本采集自墨西哥尤卡坦州。利用雄性白化小鼠测试蜂蜜的伤口愈合和抗炎特性,并分别用吡非尼酮(KitosCell®)和吲哚美辛(1 毫克/毫升和 30 毫克/毫升)作为阳性对照。结果从第一天起,观察到伤口愈合、肉芽组织形成和伤口边缘持续收缩的情况都有所改善。在抗炎活性方面,蜂蜜剂量与接受 1 毫克/毫升吲哚美辛的对照组相比,能够减轻水肿。然而,与 30 毫克/毫升吲哚美辛对照组相比,其中三组的效果存在差异。结论可以得出结论,贝壳杉属蜂蜜的伤口愈合和消炎效果与本研究中使用的阳性对照组相当。因此,它为伤口的局部治疗提供了一种可行的替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In Vivo Wound-Healing and Anti-Inflammatory Activities of Honey Produced by Melipona beecheii Bees
Background: Honey produced by the Melipona beecheii bees has been highly prized in Mexico since pre-Hispanic times for its therapeutic properties, particularly in wound healing. Objectives: The aim of this study was to assess the in vivo wound-healing and anti-inflammatory effects of M. beecheii honey using an animal model. Methods: Honey samples were collected from the state of Yucatan, Mexico. Male albino mice were utilized to test the wound-healing and anti-inflammatory properties of the honey, with pirfenidone (KitosCell®) and indomethacin (1 and 30 mg/mL) serving as positive controls, respectively. Results: From day one, enhancements in wound healing, granulation tissue formation, and continuous contraction of the wound edges were observed. In terms of anti-inflammatory activity, the honey dose was capable of reducing edema comparably to the control group receiving 1 mg/mL of indomethacin. However, differences were noted when compared to the 30 mg/mL indomethacin control group in three of the groups. Conclusions: It can be concluded that M. beecheii honey exhibits wound-healing and anti-inflammatory effects comparable to those of the positive controls used in this study. Therefore, it offers a viable alternative for the topical treatment of wounds.
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CiteScore
1.40
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