在 TARGET-NASH 真实世界队列中，非酒精性脂肪肝与代谢功能障碍相关性脂肪性肝病高度一致。

The American Journal of Gastroenterology Pub Date : 2024-04-08 DOI:10.14309/ajg.0000000000002796

A. Barritt, Feng Yu, Andrea R. Mospan, Philip Newsome, M. Roden, Heather L Morris, R. Loomba, B. Neuschwander‐Tetri

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引用次数: 0

摘要

引言本研究调查了新的 MASLD 命名法在真实世界 TARGET-NASH 美国成人队列中的适用性。方法将新的 MASLD/MASH 命名法应用于实际诊断为非酒精性脂肪肝、NASH 和 NASH 肝硬化的入组患者，并确定定义之间的一致性。1484/1541（96.3%，kappa 0.974）名 NAFL 患者（MASL）、2195/2201（99.7%，kappa 0.998）名 NASH 患者（MASH）和 1999/2003 （99.8%，kappa 0.999）名 NASH 肝硬化患者符合新标准。

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High concordance between nonalcoholic fatty liver disease and metabolic dysfunction associated steatotic liver disease in the TARGET-NASH real world cohort.

INTRODUCTION This study investigates the applicability of the new MASLD nomenclature to the real-world TARGET-NASH US adult cohort. METHODS The new MASLD/MASH nomenclature was applied to patients enrolled with pragmatic diagnoses of NAFL, NASH and NASH cirrhosis and concordance was determined between the definitions. RESULTS 99% of TARGET-NASH participants met the new MASLD diagnostic criteria. 1484/1541 (96.3%, kappa 0.974) NAFL patients (MASL), 2195/2201 (99.7%, kappa 0.998) NASH patients (MASH), and 1999/2003 (99.8%, kappa 0.999) NASH cirrhosis patients met the new criteria. CONCLUSION The new MASLD nomenclature is highly concordant with the prior TARGET-NASH pragmatic definitions.

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The American Journal of Gastroenterology

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