猫肝脂质沉着症的白细胞指数

L. Karpenko, A. I. Kozitsyna, A. Bakhta
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摘要

慢性肝功能衰竭的特点是由于长期暴露于某种破坏性因素而导致肝功能严重受损。在猫科动物中,最常见的肝脏疾病之一是脂质沉着病或脂肪肝--这是一种由于复杂的代谢紊乱(例如肥胖、能量代谢受损)而导致肝细胞中脂肪过度积聚的疾病。由于多种因素的影响,猫肝病的诊断和预后可能会出现困难,因此,寻找和评估可用的微创诊断方法以进行早期检测和治疗策略规划具有重要意义。白细胞指数就是其中一种机制。白细胞指数可以反映神经-体液反应程度和人体对各种刺激的反应,尤其是对肝脏解毒功能下降的反应,因此有助于诊断肝脏疾病。本研究的目的是以肝脂质沉着病为例,评估和比较患有慢性退行性肝病的猫的白细胞指数指标与临床健康动物的相应指标。研究发现,与淋巴细胞和中性粒细胞水平相关的白细胞指数存在显著偏差,因此可以全面评估白图参数。在兽医实践中引入和使用这些指标,可以更好地预测疾病的进程,更好地制定治疗策略。应该指出的是,为了更准确地确定诊断意义和确定预测的可能性,有必要增加动态评估指标的动物样本数量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Leukocyte indexes for liver lipidosis in cats
Chronic liver failure is characterized by significant impairment of liver function due to exposure to a damaging factor for a long time. In cats, one of the most common liver diseases is lipidosis, or fatty liver dystrophy – a condition in which there is an excessive accumulation of fats in hepatocytes caused by a complex of metabolic disorders (for example, obesity, impaired energy metabolism). Diagnosis and prognosis of the course of liver diseases in cats can cause difficulties due to a number of factors, therefore, it is relevant to search and evaluate available and minimally invasive diagnostic methods for early detection and treatment strategy planning. Leukocyte indices can be one of these mechanisms. They can be useful in the diagnosis of liver diseases, as they reflect the degree of neuro-humoral reactivity and the body's response to various stimuli, in particular, to a decrease in detoxification function of the liver. The purpose of the presented study was to evaluate and compare the indicators of leukocyte indices in cats with chronic degenerative liver disease using the example of liver lipidosis with the corresponding indicators of clinically healthy animals. significant deviations of leukocyte indices associated with the level of lymphocytes and neutrophils were revealed, which allow a comprehensive assessment of leukogram parameters. The introduction and use of these indicators in veterinary practice will make it possible to better predict the course of the disease and better develop a treatment strategy. It should be noted that in order to more accurately determine the diagnostic significance and the possibility of determining forecasts, it is necessary to increase the number of animal samples with an assessment of indicators in dynamics.
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