肠内喂养的时间和基质是早产儿视网膜病变的风险因素

Q4 Medicine

Journal of Neonatology Pub Date : 2024-04-08 DOI:10.1177/09732179241234181

A. Anderson-Berry, Yinxi Yu, M. Thoene, Gui-Shuang Ying, L. Tomlinson, G. Binenbaum

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引用次数: 0

摘要

肠内喂养比肠外营养更有优势，因此我们的目标是评估肠内喂养的时间和底物对早产儿视网膜病变（ROP）发病风险的影响。回顾性队列研究对 2006-2012 年期间在北美和加拿大 29 家医院接受 ROP 检查的 7483 名早产儿进行了研究（G-ROP 研究）。多变量回归评估了出生后一周内肠内喂养与任何或严重早产儿视网膜病变之间的关系，并对出生体重和胎龄进行了调整。3,224 例（43.1%）患上了视网膜病变，931 例（12.4%）患上了重度视网膜病变。与未进行肠道喂养相比，任何肠道喂养均可在 1-6 周内对视网膜病变起到保护作用；任何视网膜病变的几率比为 0.50-0.74 ( P < .0001 至 P < .02) ，重度视网膜病变的几率比为 0.43-0.59 ( P < .02 至 P = .0001)。在该队列中，出生后最初六周内的任何一次肠内喂养都与较低的视网膜病变和严重视网膜病变几率相关。

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Timing and Substrate of Enteral Feeding as Risk Factors for Developing Retinopathy of Prematurity

Enteral feeding has advantages over parenteral nutrition, so the objective is to evaluate the effects of timing and substrate of enteral feeding on the risk of developing retinopathy of prematurity (ROP). Retrospective cohort study of 7,483 premature infants undergoing ROP examinations at 29 North American and Canadian hospitals, 2006–2012 (The G-ROP Study). Multivariable regression evaluated associations between enteral feeding by week of life and any or severe ROP, adjusting for birth weight and gestational age. 3,224 (43.1%) had ROP and 931(12.4%) severe ROP. Compared to no enteral feeding, any enteral feeding was independently protective for ROP in all weeks 1–6; odds ratios 0.50–0.74 ( P < .0001 to P < .02) for any ROP and 0.43–0.59 ( P < .02 to P = .0001) for SEVERE ROP. In this cohort, any substrate of enteral feeding during each of the first SIX weeks of life was associated with lower odds of ROP and severe ROP.

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来源期刊

Journal of Neonatology Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.30

自引率

0.00%

发文量