胶原蛋白的生物医学应用:综述

Mashiur Rahman, M. Huda, Anamul Hasan, Mala Khan
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引用次数: 0

摘要

胶原蛋白是一种优良的生物材料。胶原蛋白的生物降解性和弱抗原性等生物特性使其成为医疗应用的主要资源。在生物医学领域,胶原蛋白主要用作治疗伤口/烧伤的海绵、类风湿性关节炎的辅助材料、给药系统、透皮给药的控制材料以及细胞培养系统的基本基质,因为胶原蛋白具有刺激组织和器官形成的能力。此外,胶原蛋白还可应用于组织工程,包括骨缺损、组织再生、皮肤替代以及人造血管和瓣膜。文章回顾了胶原蛋白在伤口愈合、类风湿性关节炎、给药系统、组织工程和改善病毒感染所致肺纤维化的肺功能等方面的生物医学应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomedical applications of collagen: A Review
Collagen is an excellent biomaterial. Biological characteristics of collagen including biodegradability and weak antigenicity made it a primary resource in medical application. In biomedical field collagen is mainly used as sponges for wound/burn, supplement in rheumatoid arthritis, drug delivery system, controlling material for transdermal delivery and basic matrices for cell culture system due to its ability to stimulate formation of tissue and organ. Moreover, collagen is also applied in tissue engineering including bone defect, tissue regeneration, skin replacement and artificial blood vessels and valves. The article reviews biomedical application of collagen in wound healing, rheumatoid arthritis, drug delivery system, tissue engineering and lung function improvement in pulmonary fibrosis due to viral infection.
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