外界面由纤维素纳米晶体稳定的双层乳剂中共同封装的绿原酸和姜黄素的体外胃肠道释放量

Javier Paredes-Toledo, Javier Herrera, Paulo Díaz-Calderón, Paz Robert, Begoña Giménez
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引用次数: 0

摘要

我们设计了一种外层(O:W2)界面由纤维素纳米晶体稳定的皮克林双乳液(DE)(DE-CNC),作为绿原酸(CA)和姜黄素的联合给药系统,并将其与外层(O:W2)界面由酪蛋白酸钠稳定的对照双乳液(DE-NaCas)进行了比较。DE-CNC在储存过程中更不易起皱(6.79%,第42天),对CA的包封效率(EE)也更高(大于90%)。相反,这两种 DE 对姜黄素的 EE 也同样高(>97%)。两种 DE 的ζ电位值均为高度负值,但由于 CNC 带有高度负电荷,DE-CNC 的ζ电位值往往较低。DE-CNC 可使 CA 在口腔、胃和肠道消化阶段稳定释放,而 DE-NaCas 在胃阶段就已观察到 CA 的完全释放。两种 DE 中 CA 的生物可及性相似(约为 57-58%)。两种 DE 均主要在肠道阶段释放姜黄素,DE-CNC 的生物可及性值略低。使用 CNC 作为 DE 外界面的稳定剂是提高这些系统稳定性和 EE 的一种有前途的策略,它提供的口服协同给药载体能够在肠道消化阶段释放大量生物活性化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In Vitro Gastrointestinal Release of Chlorogenic Acid and Curcumin Co-Encapsulated in Double Emulsions with the Outer Interface Stabilized by Cellulose Nanocrystals
A Pickering double emulsion (DE) with an outer (O:W2) interface stabilized by cellulose nanocrystals (DE-CNC) was designed as a co-delivery systems for chlorogenic acid (CA) and curcumin, then compared with a control DE emulsion with an O:W2 interface stabilized with sodium caseinate (DE-NaCas). DE-CNC was more resistant to creaming during storage (6.79%, day 42) and showed higher encapsulation efficiency (EE) of CA (>90%). Conversely, both DEs exhibited similarly high EE for curcumin (>97%). The ζ-potential values were highly negative in both DEs, but tended to be lower in DE-CNC due to the highly negative charge of the CNCs. DE-CNC allowed for a steady release of CA during the oral, gastric, and intestinal phases of digestion, while a total release of CA was already observed in the gastric phase in case of DE-NaCas. The bioaccessibility of CA was similar in both DEs (~57–58%). Curcumin was mainly released in the intestinal phase with both DEs, reaching slightly lower bioaccessibility values with DE-CNC. The use of CNCs as a stabilizer for the outer interface of DEs is a promising strategy to increase the stability and EE of these systems, providing oral co-delivery vehicles capable of releasing significantly bioactive compounds during the intestinal phase of digestion.
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