David Mantle, Hannah Rowbottom, Jacob Jones, Indiia Margarita Potts, Nadia Turton, Mollie Dewsbury, Guillermo López-Lluch, Iain P Hargreaves
{"title":"作为癌症治疗靶点的能量代谢：辅酶Q10的作用","authors":"David Mantle, Hannah Rowbottom, Jacob Jones, Indiia Margarita Potts, Nadia Turton, Mollie Dewsbury, Guillermo López-Lluch, Iain P Hargreaves","doi":"10.3390/oxygen4020008","DOIUrl":null,"url":null,"abstract":"The generation of energy within cells is a fundamental process enabling cell survival, and as such it represents a potential target in cancer therapy. In this article, we therefore review the relative contributions of glycolysis and oxidative phosphorylation/mitochondrial function to cancer cell energy generation, and we highlight their respective potential value as chemotherapeutic targets. This article is particularly focussed on the potential role of coenzyme Q10 in the prevention and treatment of cancer.","PeriodicalId":516952,"journal":{"name":"Oxygen","volume":"43 4","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Energy Metabolism as a Therapeutic Target in Cancer: The Role of Coenzyme Q10\",\"authors\":\"David Mantle, Hannah Rowbottom, Jacob Jones, Indiia Margarita Potts, Nadia Turton, Mollie Dewsbury, Guillermo López-Lluch, Iain P Hargreaves\",\"doi\":\"10.3390/oxygen4020008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The generation of energy within cells is a fundamental process enabling cell survival, and as such it represents a potential target in cancer therapy. In this article, we therefore review the relative contributions of glycolysis and oxidative phosphorylation/mitochondrial function to cancer cell energy generation, and we highlight their respective potential value as chemotherapeutic targets. This article is particularly focussed on the potential role of coenzyme Q10 in the prevention and treatment of cancer.\",\"PeriodicalId\":516952,\"journal\":{\"name\":\"Oxygen\",\"volume\":\"43 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oxygen\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/oxygen4020008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oxygen","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/oxygen4020008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Energy Metabolism as a Therapeutic Target in Cancer: The Role of Coenzyme Q10
The generation of energy within cells is a fundamental process enabling cell survival, and as such it represents a potential target in cancer therapy. In this article, we therefore review the relative contributions of glycolysis and oxidative phosphorylation/mitochondrial function to cancer cell energy generation, and we highlight their respective potential value as chemotherapeutic targets. This article is particularly focussed on the potential role of coenzyme Q10 in the prevention and treatment of cancer.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
