珊瑚启发的抗生物膜治疗基台是预防和治疗种植体周围感染的新范例

SmartMat Pub Date : 2024-04-12 DOI:10.1002/smm2.1284
Weiran Li, Zhike Huang, Xin Li, Mengqi Zhang, Qianqian Li, Shulu Luo, Yan Li, Dingcai Wu, Shuyi Wu
{"title":"珊瑚启发的抗生物膜治疗基台是预防和治疗种植体周围感染的新范例","authors":"Weiran Li, Zhike Huang, Xin Li, Mengqi Zhang, Qianqian Li, Shulu Luo, Yan Li, Dingcai Wu, Shuyi Wu","doi":"10.1002/smm2.1284","DOIUrl":null,"url":null,"abstract":"Peri‐implant infection is one of the major causes for implant failure. The transmucosal/transcutaneous surface of implant abutment is directly connected to the external environment and constantly exposed to a large number of bacteria. Establishing a robust anti‐biofilm barrier at the abutment surface to minimize the risk of peri‐implant infection is highly desirable in the field of dental implantology but remains challenging. Herein, a new class of therapeutic abutments featuring excellent anti‐biofilm performance is developed, which is achieved by admirably integrating the outstanding self‐cleaning property of polyethylene glycol and the long‐lasting renewable antibacterial property of N‐halamine. Through a comprehensive series of in vitro and in vivo experiments closely mimicking clinical conditions, therapeutic abutments have been successfully demonstrated to possess the ability of inhibiting biofilm accumulation to prevent peri‐implant infection, as well as to achieve persistent and accurate administration to reverse early‐stage peri‐implant infection. Furthermore, the therapeutic abutment could be repeatedly used, representing the characteristic of sustainable medical devices. These findings indicate a new paradigm for the prevention and treatment of peri‐implant infection.","PeriodicalId":21794,"journal":{"name":"SmartMat","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coral‐inspired anti‐biofilm therapeutic abutments as a new paradigm for prevention and treatment of peri‐implant infection\",\"authors\":\"Weiran Li, Zhike Huang, Xin Li, Mengqi Zhang, Qianqian Li, Shulu Luo, Yan Li, Dingcai Wu, Shuyi Wu\",\"doi\":\"10.1002/smm2.1284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Peri‐implant infection is one of the major causes for implant failure. The transmucosal/transcutaneous surface of implant abutment is directly connected to the external environment and constantly exposed to a large number of bacteria. Establishing a robust anti‐biofilm barrier at the abutment surface to minimize the risk of peri‐implant infection is highly desirable in the field of dental implantology but remains challenging. Herein, a new class of therapeutic abutments featuring excellent anti‐biofilm performance is developed, which is achieved by admirably integrating the outstanding self‐cleaning property of polyethylene glycol and the long‐lasting renewable antibacterial property of N‐halamine. Through a comprehensive series of in vitro and in vivo experiments closely mimicking clinical conditions, therapeutic abutments have been successfully demonstrated to possess the ability of inhibiting biofilm accumulation to prevent peri‐implant infection, as well as to achieve persistent and accurate administration to reverse early‐stage peri‐implant infection. Furthermore, the therapeutic abutment could be repeatedly used, representing the characteristic of sustainable medical devices. These findings indicate a new paradigm for the prevention and treatment of peri‐implant infection.\",\"PeriodicalId\":21794,\"journal\":{\"name\":\"SmartMat\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SmartMat\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/smm2.1284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SmartMat","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smm2.1284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

种植体周围感染是种植失败的主要原因之一。种植体基台的经粘膜/经皮表面直接与外部环境相连,经常暴露在大量细菌的环境中。在基台表面建立稳固的抗生物膜屏障以最大限度地降低种植体周围感染的风险是牙科种植领域的一大愿望,但目前仍面临挑战。在这里,我们开发出了一种新型治疗基台,它具有卓越的抗生物膜性能,将聚乙二醇出色的自洁性能和 N-哈拉敏持久的可再生抗菌性能完美地结合在了一起。通过一系列密切模拟临床条件的体外和体内综合实验,成功证明了治疗基台具有抑制生物膜积聚以预防种植体周围感染的能力,并能实现持续、准确的给药以逆转早期种植体周围感染。此外,这种治疗基台可以反复使用,体现了可持续医疗器械的特点。这些发现为预防和治疗种植体周围感染提供了新的范例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coral‐inspired anti‐biofilm therapeutic abutments as a new paradigm for prevention and treatment of peri‐implant infection
Peri‐implant infection is one of the major causes for implant failure. The transmucosal/transcutaneous surface of implant abutment is directly connected to the external environment and constantly exposed to a large number of bacteria. Establishing a robust anti‐biofilm barrier at the abutment surface to minimize the risk of peri‐implant infection is highly desirable in the field of dental implantology but remains challenging. Herein, a new class of therapeutic abutments featuring excellent anti‐biofilm performance is developed, which is achieved by admirably integrating the outstanding self‐cleaning property of polyethylene glycol and the long‐lasting renewable antibacterial property of N‐halamine. Through a comprehensive series of in vitro and in vivo experiments closely mimicking clinical conditions, therapeutic abutments have been successfully demonstrated to possess the ability of inhibiting biofilm accumulation to prevent peri‐implant infection, as well as to achieve persistent and accurate administration to reverse early‐stage peri‐implant infection. Furthermore, the therapeutic abutment could be repeatedly used, representing the characteristic of sustainable medical devices. These findings indicate a new paradigm for the prevention and treatment of peri‐implant infection.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信