H. Herfarth, M. Long, Jonathan J Hansen, Chelsea Anderson, Emily English, John B. Buse, Edward L Barnes
{"title":"利拉鲁肽对回肠袋-肛门吻合术患者和慢性高肠频率患者的疗效和安全性:安慰剂对照、交叉、概念验证研究。","authors":"H. Herfarth, M. Long, Jonathan J Hansen, Chelsea Anderson, Emily English, John B. Buse, Edward L Barnes","doi":"10.14309/ajg.0000000000002801","DOIUrl":null,"url":null,"abstract":"Introduction\nAfter colectomy with ileo-anal pouch anastomosis (IPAA), many patients develop high bowel frequency (BF) refractory to antimotility agents despite normal IPAA morphology. Low circulating levels of glucagon-like protein-1 (GLP-1), a modulator of gastroduodenal motility, have been reported after colectomy.\n\n\nMethods\nDouble-blind crossover study of 8 IPAA patients with refractory high BF treated with daily administration of the GLP-1 receptor agonist (GLP-1-RA) liraglutide or placebo.\n\n\nResults\nLiraglutide, but not placebo, reduced daily BF by more than 35% (P<0.03).\n\n\nDiscussion\nLarger randomized controlled studies are warranted to delineate the treatment potential of GLP-1RA's in IPAA patients suffering from non-inflammatory high BF.","PeriodicalId":507623,"journal":{"name":"The American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy and safety of liraglutide in patients with patients with an ileal pouch-anal anastomosis and chronic high bowel frequency: A placebo-controlled, crossover, proof of concept study.\",\"authors\":\"H. Herfarth, M. Long, Jonathan J Hansen, Chelsea Anderson, Emily English, John B. Buse, Edward L Barnes\",\"doi\":\"10.14309/ajg.0000000000002801\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction\\nAfter colectomy with ileo-anal pouch anastomosis (IPAA), many patients develop high bowel frequency (BF) refractory to antimotility agents despite normal IPAA morphology. Low circulating levels of glucagon-like protein-1 (GLP-1), a modulator of gastroduodenal motility, have been reported after colectomy.\\n\\n\\nMethods\\nDouble-blind crossover study of 8 IPAA patients with refractory high BF treated with daily administration of the GLP-1 receptor agonist (GLP-1-RA) liraglutide or placebo.\\n\\n\\nResults\\nLiraglutide, but not placebo, reduced daily BF by more than 35% (P<0.03).\\n\\n\\nDiscussion\\nLarger randomized controlled studies are warranted to delineate the treatment potential of GLP-1RA's in IPAA patients suffering from non-inflammatory high BF.\",\"PeriodicalId\":507623,\"journal\":{\"name\":\"The American Journal of Gastroenterology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The American Journal of Gastroenterology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14309/ajg.0000000000002801\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American Journal of Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14309/ajg.0000000000002801","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Efficacy and safety of liraglutide in patients with patients with an ileal pouch-anal anastomosis and chronic high bowel frequency: A placebo-controlled, crossover, proof of concept study.
Introduction
After colectomy with ileo-anal pouch anastomosis (IPAA), many patients develop high bowel frequency (BF) refractory to antimotility agents despite normal IPAA morphology. Low circulating levels of glucagon-like protein-1 (GLP-1), a modulator of gastroduodenal motility, have been reported after colectomy.
Methods
Double-blind crossover study of 8 IPAA patients with refractory high BF treated with daily administration of the GLP-1 receptor agonist (GLP-1-RA) liraglutide or placebo.
Results
Liraglutide, but not placebo, reduced daily BF by more than 35% (P<0.03).
Discussion
Larger randomized controlled studies are warranted to delineate the treatment potential of GLP-1RA's in IPAA patients suffering from non-inflammatory high BF.