儿童医院医护人员 SARS-CoV-2 血清流行率筛查研究

Pub Date : 2024-04-14 DOI:10.1177/17571774241245260
Olivia Pluss, Stephen Berman, Molly Lamb, Vijaya Knight, Yannik E. Roell, Steven Berkowitz, Thomas Jaenisch
{"title":"儿童医院医护人员 SARS-CoV-2 血清流行率筛查研究","authors":"Olivia Pluss, Stephen Berman, Molly Lamb, Vijaya Knight, Yannik E. Roell, Steven Berkowitz, Thomas Jaenisch","doi":"10.1177/17571774241245260","DOIUrl":null,"url":null,"abstract":"Health care workers (HCWs) are front line responders to the COVID-19 pandemic, but limited data is available for pediatric HCWs, as the research response has largely focused on adult patients and medical personnel that treat these patients. We conducted a cross-sectional study of SARS-CoV-2 seroprevalence and risk factors in HCWs at a Children’s Hospital in CO, USA from September 2020 to April 2021. Pediatric HCWs were defined as clinical care providers and administrative staff. Seroprevalence was determined using the Epitope SARS-CoV-2 anti-Nucleocapsid IgG assay (San Diego, CA) and the Euroimmun SARS-CoV-2 anti-Spike Protein IgG assay. Risk factors and vaccination status were assessed via questionnaire. Overall, 110 HCWs were enrolled, 79 subjects were positive for anti-S antibodies and negative for anti-N antibodies, indicating COVID-19 vaccination. 31 subjects had neither anti-N or anti-S antibodies, indicating no exposure to SARS-CoV-2 and no vaccination. 3/110 had a nucleocapsid serology consistent with a SARS-CoV-2 prior infection. Seroprevalence was observed at 2.7%. It was noted that asthma requiring medication was associated with positive serostatus. During the winter 2020/21, SARS-CoV-2, we found a 2.7% seroprevalence of pediatric HCW at a children’s hospital in Colorado. We compared this with publicly available seroprevalence data for seroprevalence rates of pediatric HCWs globally. This suggests that this specific children’s hospital COVID-19 personal protective equipment (PPE) and infection control guidelines were effective in limiting SARS-CoV-2 in hospital transmission at the children’s hospital prior to the presence of the Delta variant.","PeriodicalId":0,"journal":{"name":"","volume":"119 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SARS-CoV-2 seroprevalence screening study of a children’s hospital health care workers\",\"authors\":\"Olivia Pluss, Stephen Berman, Molly Lamb, Vijaya Knight, Yannik E. Roell, Steven Berkowitz, Thomas Jaenisch\",\"doi\":\"10.1177/17571774241245260\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Health care workers (HCWs) are front line responders to the COVID-19 pandemic, but limited data is available for pediatric HCWs, as the research response has largely focused on adult patients and medical personnel that treat these patients. We conducted a cross-sectional study of SARS-CoV-2 seroprevalence and risk factors in HCWs at a Children’s Hospital in CO, USA from September 2020 to April 2021. Pediatric HCWs were defined as clinical care providers and administrative staff. Seroprevalence was determined using the Epitope SARS-CoV-2 anti-Nucleocapsid IgG assay (San Diego, CA) and the Euroimmun SARS-CoV-2 anti-Spike Protein IgG assay. Risk factors and vaccination status were assessed via questionnaire. Overall, 110 HCWs were enrolled, 79 subjects were positive for anti-S antibodies and negative for anti-N antibodies, indicating COVID-19 vaccination. 31 subjects had neither anti-N or anti-S antibodies, indicating no exposure to SARS-CoV-2 and no vaccination. 3/110 had a nucleocapsid serology consistent with a SARS-CoV-2 prior infection. Seroprevalence was observed at 2.7%. It was noted that asthma requiring medication was associated with positive serostatus. During the winter 2020/21, SARS-CoV-2, we found a 2.7% seroprevalence of pediatric HCW at a children’s hospital in Colorado. We compared this with publicly available seroprevalence data for seroprevalence rates of pediatric HCWs globally. This suggests that this specific children’s hospital COVID-19 personal protective equipment (PPE) and infection control guidelines were effective in limiting SARS-CoV-2 in hospital transmission at the children’s hospital prior to the presence of the Delta variant.\",\"PeriodicalId\":0,\"journal\":{\"name\":\"\",\"volume\":\"119 4\",\"pages\":\"\"},\"PeriodicalIF\":0.0,\"publicationDate\":\"2024-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/17571774241245260\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/17571774241245260","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

医护人员(HCWs)是应对 COVID-19 大流行的第一线人员,但目前关于儿科医护人员的数据非常有限,因为研究主要集中在成年患者和治疗这些患者的医务人员身上。我们于 2020 年 9 月至 2021 年 4 月在美国科罗拉多州的一家儿童医院开展了一项横断面研究,目的是了解儿科医护人员的 SARS-CoV-2 血清流行率和风险因素。儿科医护人员是指临床护理人员和行政人员。使用 Epitope SARS-CoV-2 抗核头壳 IgG 检测试剂盒(加利福尼亚州圣地亚哥)和 Euroimmun SARS-CoV-2 抗尖峰蛋白 IgG 检测试剂盒测定血清流行率。通过问卷调查评估了风险因素和疫苗接种情况。总共有 110 名高危工人被纳入调查,其中 79 人的抗 S 抗体呈阳性,抗 N 抗体呈阴性,这表明他们接种了 COVID-19 疫苗。31 名受试者既没有抗 N 抗体,也没有抗 S 抗体,这表明他们没有接触过 SARS-CoV-2 也没有接种过疫苗。3/110的受试者的核壳血清与之前感染过SARS-CoV-2的结果一致。血清流行率为 2.7%。据指出,需要药物治疗的哮喘与阳性血清状态有关。在 2020/21 年冬季的 SARS-CoV-2 期间,我们发现科罗拉多州一家儿童医院的儿科医护人员血清阳性率为 2.7%。我们将这一数据与全球儿科医护人员血清阳性率的公开数据进行了比较。这表明,在德尔塔变异体出现之前,该儿童医院的 COVID-19 个人防护设备(PPE)和感染控制指南能有效限制 SARS-CoV-2 在医院的传播。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
分享
查看原文
SARS-CoV-2 seroprevalence screening study of a children’s hospital health care workers
Health care workers (HCWs) are front line responders to the COVID-19 pandemic, but limited data is available for pediatric HCWs, as the research response has largely focused on adult patients and medical personnel that treat these patients. We conducted a cross-sectional study of SARS-CoV-2 seroprevalence and risk factors in HCWs at a Children’s Hospital in CO, USA from September 2020 to April 2021. Pediatric HCWs were defined as clinical care providers and administrative staff. Seroprevalence was determined using the Epitope SARS-CoV-2 anti-Nucleocapsid IgG assay (San Diego, CA) and the Euroimmun SARS-CoV-2 anti-Spike Protein IgG assay. Risk factors and vaccination status were assessed via questionnaire. Overall, 110 HCWs were enrolled, 79 subjects were positive for anti-S antibodies and negative for anti-N antibodies, indicating COVID-19 vaccination. 31 subjects had neither anti-N or anti-S antibodies, indicating no exposure to SARS-CoV-2 and no vaccination. 3/110 had a nucleocapsid serology consistent with a SARS-CoV-2 prior infection. Seroprevalence was observed at 2.7%. It was noted that asthma requiring medication was associated with positive serostatus. During the winter 2020/21, SARS-CoV-2, we found a 2.7% seroprevalence of pediatric HCW at a children’s hospital in Colorado. We compared this with publicly available seroprevalence data for seroprevalence rates of pediatric HCWs globally. This suggests that this specific children’s hospital COVID-19 personal protective equipment (PPE) and infection control guidelines were effective in limiting SARS-CoV-2 in hospital transmission at the children’s hospital prior to the presence of the Delta variant.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信