儿童医院医护人员 SARS-CoV-2 血清流行率筛查研究

IF 0.9 Q4 INFECTIOUS DISEASES
Olivia Pluss, Stephen Berman, Molly Lamb, Vijaya Knight, Yannik E. Roell, Steven Berkowitz, Thomas Jaenisch
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引用次数: 0

摘要

医护人员(HCWs)是应对 COVID-19 大流行的第一线人员,但目前关于儿科医护人员的数据非常有限,因为研究主要集中在成年患者和治疗这些患者的医务人员身上。我们于 2020 年 9 月至 2021 年 4 月在美国科罗拉多州的一家儿童医院开展了一项横断面研究,目的是了解儿科医护人员的 SARS-CoV-2 血清流行率和风险因素。儿科医护人员是指临床护理人员和行政人员。使用 Epitope SARS-CoV-2 抗核头壳 IgG 检测试剂盒(加利福尼亚州圣地亚哥)和 Euroimmun SARS-CoV-2 抗尖峰蛋白 IgG 检测试剂盒测定血清流行率。通过问卷调查评估了风险因素和疫苗接种情况。总共有 110 名高危工人被纳入调查,其中 79 人的抗 S 抗体呈阳性,抗 N 抗体呈阴性,这表明他们接种了 COVID-19 疫苗。31 名受试者既没有抗 N 抗体,也没有抗 S 抗体,这表明他们没有接触过 SARS-CoV-2 也没有接种过疫苗。3/110的受试者的核壳血清与之前感染过SARS-CoV-2的结果一致。血清流行率为 2.7%。据指出,需要药物治疗的哮喘与阳性血清状态有关。在 2020/21 年冬季的 SARS-CoV-2 期间,我们发现科罗拉多州一家儿童医院的儿科医护人员血清阳性率为 2.7%。我们将这一数据与全球儿科医护人员血清阳性率的公开数据进行了比较。这表明,在德尔塔变异体出现之前,该儿童医院的 COVID-19 个人防护设备(PPE)和感染控制指南能有效限制 SARS-CoV-2 在医院的传播。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SARS-CoV-2 seroprevalence screening study of a children’s hospital health care workers
Health care workers (HCWs) are front line responders to the COVID-19 pandemic, but limited data is available for pediatric HCWs, as the research response has largely focused on adult patients and medical personnel that treat these patients. We conducted a cross-sectional study of SARS-CoV-2 seroprevalence and risk factors in HCWs at a Children’s Hospital in CO, USA from September 2020 to April 2021. Pediatric HCWs were defined as clinical care providers and administrative staff. Seroprevalence was determined using the Epitope SARS-CoV-2 anti-Nucleocapsid IgG assay (San Diego, CA) and the Euroimmun SARS-CoV-2 anti-Spike Protein IgG assay. Risk factors and vaccination status were assessed via questionnaire. Overall, 110 HCWs were enrolled, 79 subjects were positive for anti-S antibodies and negative for anti-N antibodies, indicating COVID-19 vaccination. 31 subjects had neither anti-N or anti-S antibodies, indicating no exposure to SARS-CoV-2 and no vaccination. 3/110 had a nucleocapsid serology consistent with a SARS-CoV-2 prior infection. Seroprevalence was observed at 2.7%. It was noted that asthma requiring medication was associated with positive serostatus. During the winter 2020/21, SARS-CoV-2, we found a 2.7% seroprevalence of pediatric HCW at a children’s hospital in Colorado. We compared this with publicly available seroprevalence data for seroprevalence rates of pediatric HCWs globally. This suggests that this specific children’s hospital COVID-19 personal protective equipment (PPE) and infection control guidelines were effective in limiting SARS-CoV-2 in hospital transmission at the children’s hospital prior to the presence of the Delta variant.
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来源期刊
Journal of Infection Prevention
Journal of Infection Prevention Nursing-Advanced and Specialized Nursing
CiteScore
1.70
自引率
8.30%
发文量
46
期刊介绍: Journal of Infection Prevention is the professional publication of the Infection Prevention Society. The aim of the journal is to advance the evidence base in infection prevention and control, and to provide a publishing platform for all health professionals interested in this field of practice. Journal of Infection Prevention is a bi-monthly peer-reviewed publication containing a wide range of articles: ·Original primary research studies ·Qualitative and quantitative studies ·Reviews of the evidence on various topics ·Practice development project reports ·Guidelines for practice ·Case studies ·Overviews of infectious diseases and their causative organisms ·Audit and surveillance studies/projects
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