用于分析饮用水中卤乙酸的有效反相液相色谱-质谱/质谱方法:支持从 HAA5 到 HAA9 的过渡

Polly L. Grundy, Peter R. Jarvis, Bruce Jefferson, John Fawell, John A. Haley, E. Goslan
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引用次数: 0

摘要

卤乙酸(HAAs)是饮用水消毒过程中有机物和氯相互作用形成的潜在有毒副产品,当存在溴化物时会形成溴化 HAAs。一些国家要求对饮用水中的五种 HAAs 进行监测,但人们越来越关注与毒性更强的溴化 HAAs 相关的健康问题,因此对九种 HAAs(HAA9)的监测正变得越来越普遍。然而,现有的 HAA9 分析方法往往不够理想,涉及复杂的衍生步骤和/或较长的分析运行时间。本文介绍了一种改进的方法,利用反相 LC-MS/MS,样品制备只需简单的 pH 值调整,分析运行只需 10 分钟。通过对四种饮用水基质的全面验证,证明了该方法的有效性,并观察到 HAA9 具有良好的灵敏度(<0.8 μg/L)、精密度(<7%)和偏差(<10%)。使用真实的自来水样品与广泛使用的现有气相色谱电子捕获检测方法进行了直接比较。新的 LC-MS/MS 方法明显更快、更简便,在准确度和精确度方面的性能也得到了提高。这对于了解氯化水中的 HAAs 带来的风险具有重要意义,因为它消除了历史上可能存在的低估毒性更强的溴化化合物含量的情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A validated reverse-phase LC-MS/MS method for the analysis of haloacetic acids in drinking water: supporting the transition from HAA5 to HAA9
Haloacetic acids (HAAs) are potentially toxic by-products formed from interactions of organic matter and chlorine during disinfection of drinking water, with brominated HAAs forming when bromide is present. Some countries require monitoring of drinking water for five HAAs, but there is an increasing health concern related to the more toxic brominated HAAs and monitoring of nine HAAs (HAA9) is becoming more widespread. However, existing methods of analysis for HAA9 are often sub-optimal, involving complex derivatisation steps and/or long analytical run times. This article presents an improved methodology utilising reverse-phase LC-MS/MS for which sample preparation involves only simple pH adjustment and the analytical run takes 10 min. The efficacy of the method has been demonstrated by a full validation across four drinking water matrices with good sensitivity (<0.8 μg/L), precision (<7%), and bias (<10%) observed for HAA9. A direct comparison using real tap water samples was performed against the widely used existing gas chromatography electron capture the detection method. The new LC-MS/MS method was significantly quicker and easier and demonstrated improved performance in terms of accuracy and precision. This has implications for understanding the risk posed by HAAs in chlorinated water by eliminating the possible historical underestimates of the levels of the more toxic brominated compounds.
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