3-丙炔氧基-5-苄氧基苯甲酸甲酯环化产物的合成与分析表征

Molbank Pub Date : 2024-04-16 DOI:10.3390/m1806

M. Mori, Giulia Cazzaniga, Donatella Nava, Elena Pini

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引用次数: 0

摘要

在我们正在进行的关于铬烷衍生物作为结核杆菌水杨酸合成酶抑制剂的研究中，我们从 3-(丙炔氧基)-5-苄氧基苯甲酸甲酯的环化反应中分离出了一种意想不到的新化合物。我们通过一维和二维核磁共振分析、傅立叶变换红外光谱、ESI-MS 和 HRMS 等方法阐明了该化合物的分子结构。

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Synthesis and Analytical Characterization of Cyclization Products of 3-Propargyloxy-5-benzyloxy-benzoic Acid Methyl Ester

In the context of our ongoing studies on chromane derivatives as inhibitors of the salicylate synthase from M. tuberculosis, we isolated a new, unexpected compound from the cyclization of 3-(propargyloxy)-5-benzyloxy-benzoic acid methyl ester. Its molecular structure was elucidated by means of 1D and 2D NMR analyses, FT-IR, ESI-MS, and HRMS.

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Molbank

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