幼年肌阵挛性癫痫患者的认知障碍

Q4 Medicine
K. D. Lysova, I. K. Kuznetsov, A. I. Paramonova, A. A. Usoltseva, E. A. Kantimirova, N. A. Shnayder, D. V. Dmitrenko
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引用次数: 0

摘要

背景。认知障碍是与癫痫相关的主要并发症之一。在长期病程中,约70-80%的病例会出现认知功能下降。青少年肌阵挛性癫痫(JME)是最常见的癫痫形式之一(约占9.3%)。与其他形式的特发性全身性癫痫相比,JME具有发作风险高、患者对治疗的依从性低以及产生耐药性的危险性等特点,而耐药性可能是认知障碍的原因。在 eLibrary、PubMed/MEDLINE 和 Google Scholar 数据库中使用关键词及其组合进行检索:"认知障碍"、"认知障碍"、"认知功能"、"神经心理学"、"癫痫"、"幼年肌阵挛性癫痫"、"JME"、"特发性全身性癫痫"、"抗癫痫药物"。我们分析了过去 5 年发表的文章和一些具有重要科学意义的早期作品。所有文章均以英语或俄语发表。在数据库中共找到 895 篇文章。根据选择和删除重复文章的标准,对全文进行了全面筛选和资格评估,从而将 3 篇俄文科学出版物和 67 篇英文科学出版物纳入文献综述。研究分析了造成JME患者认知障碍的主要原因,并对相关的神经心理学特征进行了描述。此外,还考虑了诊断工具和目前纠正认知功能障碍的机会。JME患者认知功能障碍的根本原因是多因素的,需要进一步研究。然而,在这一患者群体中,识别和及时纠正认知障碍仍存在突出障碍。制定统一的诊断和治疗标准,开发针对癫痫认知障碍的康复方法,将有助于提高JME患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cognitive impairment in patients with juvenile myoclonic epilepsy
Background. Сognitive impairment is one of the major epilepsy-related comorbidities. Upon long-term disease course, a decline in cognitive functions occurs in about 70–80% of cases. Juvenile myoclonic epilepsy (JME) is one of the most common forms of epilepsy (about 9.3%). Compared with other forms of idiopathic generalized epilepsy, JME is featured with high risk of seizures along with lowered patient compliance to treatment as well as a danger of developing drug resistance that may be a cause of cognitive disorder.Objective: to review research publications on cognitive impairment in JME, discuss its putative causes, describe neuropsychological profile for JME patients.Material and methods. The search was carried out in eLibrary, PubMed/MEDLINE, and Google Scholar databases using keywords and their combinations: “cognitive impairment”, “cognitive disorder”, “cognitive functions”, “neuropsychology”, “epilepsy”, “juvenile myoclonic epilepsy”, “JME”, “idiopathic generalized epilepsy”, “antiepileptic drugs”. We analyzed the articles published over the past 5 years and some earlier works of significant scientific interest. All articles were published in English or Russian languages.Results. A total of 895 articles were found in databases. Comprehensive screening, evaluation of full-text articles eligibility in accordance with the criteria for selecting and deleting duplicates allowed to include 3 scientific publications in Russian and 67 scientific publications in English in the literature review. The main causes of cognitive impairment in JME patients were analyzed followed by describing relevant neuropsychological profile. Diagnostic tools and current opportunities for correction of cognitive disfunctions were considered as well.Conclusion. The underlying causes of cognitive impairment in JME patients are multifactorial in nature and require further research. However, in this patient cohort prominent obstacles remain in identifying and timely correcting such disorders. Approving uniform diagnostic and therapeutic standards, developing rehabilitation methods for cognitive impairment in epilepsy will help improve the quality of life in JME patients.
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来源期刊
Epilepsy and Paroxysmal Conditions
Epilepsy and Paroxysmal Conditions Medicine-Neurology (clinical)
CiteScore
0.90
自引率
0.00%
发文量
31
审稿时长
8 weeks
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