探索食物成瘾、超重、肥胖和端粒长度之间的关系

Obesities Pub Date : 2024-04-16 DOI:10.3390/obesities4020007
T. Aguirre, Kosuke Niitsu
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摘要

背景:食物成瘾(FA)患者是肥胖症患者中的一个特殊群体,他们对减肥干预措施的反应较差。一个新兴的研究领域正在探索端粒长度在疾病过程中的作用。一些证据表明,肥胖与端粒缩短有关;但是,我们还不知道有哪些研究对肥胖亚型的端粒长度进行了检测。因此,我们探讨了FA和肥胖程度是否与端粒缩短有关。研究方法我们招募了120名超重/肥胖(体重指数≥25)的成年人(19-70岁);其中一半人有严重食物成瘾(FA+),另一半人没有食物成瘾(FA-)(耶鲁食物成瘾量表2.0)。参与者填写了一份人口统计学表格,并提供了一份唾液样本(Oragene唾液DNA采集试剂盒)。使用单磷酸定量聚合酶链反应(qPCR)分析端粒长度。数据分析采用描述性统计、t 检验和方差分析(α = 0.05)。结果超重参与者(平均 = 1.40 t/s,标准差 = 0.40)的端粒(p = 0.013)长于病态肥胖者(平均 = 1.15 t/s,标准差 = 1.29)。FA-(平均 = 1.26 t/s,SD = 0.26)和FA+(平均 = 1.32 t/s,SD = 0.34)人群的端粒长度没有差异(p = 0.306)。与年龄最大的参与者(平均 = 1.18 t/s,SD = 0.19)相比,年龄最小的参与者(平均 = 1.39 t/s,SD = 0.33)的端粒更长(p = 0.006)。结论病态肥胖者的端粒长度最短。但有趣的是,食物成瘾亚型与非食物成瘾亚型的端粒长度差异并不明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Relationship between Food Addiction, Overweight, Obesity, and Telomere Length
Background: Individuals with food addiction (FA) compose a distinct subset of people with obesity who are less responsive to weight loss interventions. An emerging field of study explores the role of telomere length in disease processes. Some evidence suggests that obesity is associated with telomere shortening; however, we are not aware of studies examining telomere length in obesity subtypes. Therefore, we explored whether FA and levels of obesity were associated with telomere shortening. Methods: We enrolled 120 adults (aged 19–70) with overweight/obesity (BMI ≥ 25); half were positive for severe food addiction (FA+), and half were negative for food addiction (FA−) (Yale Food Addiction Scale 2.0). Participants completed a demographic form and provided a saliva sample (Oragene saliva DNA collection kit). Telomere length was analyzed using the monoplex quantitative polymerase chain reaction (qPCR). Data were analyzed using descriptive statistics, t-tests, and ANOVAs (α = 0.05). Results: Participants with overweight (mean = 1.40 t/s, SD = 0.40) had longer telomeres (p = 0.013) than those with morbid obesity (mean = 1.15 t/s, SD = 1.29). Telomere length did not differ (p = 0.306) between persons who were FA− (mean = 1.26 t/s, SD = 0.26) and those who were FA+ (mean = 1.32 t/s, SD = 0.34). The youngest participants (mean = 1.39 t/s, SD = 0.33) had longer telomeres (p = 0.006) than the oldest participants (mean = 1.18 t/s, SD = 0.19). Conclusion: Those who were morbidly obese had the shortest telomere lengths. Interestingly, however, there were not significant telomere length differences in the food addicted vs. nonfood-addicted subtypes.
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