{"title":"基于石墨片铜金属有机框架的高效非酶电化学葡萄糖生物传感器","authors":"Deepa Kumari, Megha Prajapati, Chhaya Ravi Kant","doi":"10.1149/2162-8777/ad3fe5","DOIUrl":null,"url":null,"abstract":"\n Detection of glucose is highly informative, creating a constant demand for fabricating high-precision glucose biosensors. Metal–organic frameworks, a family of porous materials renowned for their tunability, can be an excellent choice for developing such sensors. We have developed a highly-sensitive, non-enzymatic sensor for electrochemical detection of glucose fabricated using Copper Metal–Organic Framework (Cu MOF), synthesized by a simple, room-temperature stirring method using Benzene-1,3,5-tricarboxylic acid (BTC) as ligand and Copper nitrate trihydrate as precursor. The synthesized nanostructure was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray analytical techniques. Powder X-ray diffraction study and thermogravimetric analysis were also done. Further, Brunnauer-Emmett-Teller analysis revealed the porous nature of Cu MOF. The materials exhibited strong electro-catalytic activity for glucose oxidation as revealed from cyclic voltammetry and chronoamperometric studies done under alkaline pH conditions. The Cu MOF deposited on a conducting graphite sheet electrode displayed a significantly low detection limit of 0.019 mM through a broad detection range (1–15 mM) and a strong sensitivity of 229.4 μAmM-1 cm2. Overall, the Cu MOF/GS exhibits exceptional stability, short response time (less than 1s), and good repeatability and reproducibility, making it a promising future material for non-enzymatic glucose detection.","PeriodicalId":504734,"journal":{"name":"ECS Journal of Solid State Science and Technology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly Efficient Non-Enzymatic Electrochemical Glucose Biosensor Based on Copper Metal Organic Framework Coated on Graphite Sheet\",\"authors\":\"Deepa Kumari, Megha Prajapati, Chhaya Ravi Kant\",\"doi\":\"10.1149/2162-8777/ad3fe5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n Detection of glucose is highly informative, creating a constant demand for fabricating high-precision glucose biosensors. Metal–organic frameworks, a family of porous materials renowned for their tunability, can be an excellent choice for developing such sensors. We have developed a highly-sensitive, non-enzymatic sensor for electrochemical detection of glucose fabricated using Copper Metal–Organic Framework (Cu MOF), synthesized by a simple, room-temperature stirring method using Benzene-1,3,5-tricarboxylic acid (BTC) as ligand and Copper nitrate trihydrate as precursor. The synthesized nanostructure was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray analytical techniques. Powder X-ray diffraction study and thermogravimetric analysis were also done. Further, Brunnauer-Emmett-Teller analysis revealed the porous nature of Cu MOF. The materials exhibited strong electro-catalytic activity for glucose oxidation as revealed from cyclic voltammetry and chronoamperometric studies done under alkaline pH conditions. The Cu MOF deposited on a conducting graphite sheet electrode displayed a significantly low detection limit of 0.019 mM through a broad detection range (1–15 mM) and a strong sensitivity of 229.4 μAmM-1 cm2. Overall, the Cu MOF/GS exhibits exceptional stability, short response time (less than 1s), and good repeatability and reproducibility, making it a promising future material for non-enzymatic glucose detection.\",\"PeriodicalId\":504734,\"journal\":{\"name\":\"ECS Journal of Solid State Science and Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ECS Journal of Solid State Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1149/2162-8777/ad3fe5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ECS Journal of Solid State Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1149/2162-8777/ad3fe5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
葡萄糖的检测具有很高的信息量,因此对制造高精度葡萄糖生物传感器的需求不断增加。金属有机框架是以可调性著称的多孔材料系列,是开发此类传感器的绝佳选择。我们利用金属有机框架铜(Cu MOF)开发了一种用于电化学检测葡萄糖的高灵敏度非酶传感器,该传感器以苯-1,3,5-三羧酸(BTC)为配体,以三水硝酸铜为前驱体,通过简单的室温搅拌法合成。利用傅立叶变换红外光谱、扫描电子显微镜和能量色散 X 射线分析技术对合成的纳米结构进行了表征。此外,还进行了粉末 X 射线衍射研究和热重分析。此外,Brunnauer-Emmett-Teller 分析还揭示了 Cu MOF 的多孔性。在碱性 pH 条件下进行的循环伏安法和计时电流法研究表明,这些材料具有很强的葡萄糖氧化电催化活性。沉积在导电石墨片电极上的 Cu MOF 在较宽的检测范围(1-15 mM)内显示出 0.019 mM 的较低检测限和 229.4 μAmM-1 cm2 的较高灵敏度。总之,Cu MOF/GS 具有优异的稳定性、较短的响应时间(小于 1 秒)以及良好的重复性和再现性,使其成为一种很有前途的非酶葡萄糖检测材料。
Highly Efficient Non-Enzymatic Electrochemical Glucose Biosensor Based on Copper Metal Organic Framework Coated on Graphite Sheet
Detection of glucose is highly informative, creating a constant demand for fabricating high-precision glucose biosensors. Metal–organic frameworks, a family of porous materials renowned for their tunability, can be an excellent choice for developing such sensors. We have developed a highly-sensitive, non-enzymatic sensor for electrochemical detection of glucose fabricated using Copper Metal–Organic Framework (Cu MOF), synthesized by a simple, room-temperature stirring method using Benzene-1,3,5-tricarboxylic acid (BTC) as ligand and Copper nitrate trihydrate as precursor. The synthesized nanostructure was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray analytical techniques. Powder X-ray diffraction study and thermogravimetric analysis were also done. Further, Brunnauer-Emmett-Teller analysis revealed the porous nature of Cu MOF. The materials exhibited strong electro-catalytic activity for glucose oxidation as revealed from cyclic voltammetry and chronoamperometric studies done under alkaline pH conditions. The Cu MOF deposited on a conducting graphite sheet electrode displayed a significantly low detection limit of 0.019 mM through a broad detection range (1–15 mM) and a strong sensitivity of 229.4 μAmM-1 cm2. Overall, the Cu MOF/GS exhibits exceptional stability, short response time (less than 1s), and good repeatability and reproducibility, making it a promising future material for non-enzymatic glucose detection.