通过修复肠道屏障，驯化的毛地黄乙醇提取物可减轻DSS诱发的溃疡性结肠炎

IF 2.4 3区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

Food Science and Biotechnology Pub Date : 2024-04-18 DOI:10.1007/s10068-024-01565-5

Jianyuan Kang, Weicang Xie, Lingping Wu, Yuanyuan Liu, Youcai Xu, Yifei Xu, Yanzhen Mai, Lisheng Peng, Bin Huang, Shaoju Guo, Shuang Luo

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引用次数: 0

摘要

以前的研究发现，Amauroderma rugosum (Blume and T. Nees) Torrend（Ganodermataceae）（A. rugosum）具有抗炎能力。本研究旨在验证 A. rugosum 在治疗溃疡性结肠炎方面的疗效，并研究其潜在的作用机制。通过给小鼠喂食添加了右旋糖酐硫酸钠（DSS）的饮用水，诱发急性实验性溃疡性结肠炎。研究结果表明，驯化 A. rugosum 的乙醇提取物在减轻临床症状和结肠病理评分方面的疗效与 Salazosulfapyridine（SASP）相当。此外，A. rugosum 还能增强紧密连接（TJ）蛋白的表达，同时降低 TNF-ɑ 和 IL-6 的水平。值得注意的是，它还能减少 NF-κB p65 的核转位。总之，A. rugosum 可通过增强肠道屏障功能和抑制粘膜炎症来减轻 DSS 引起的溃疡性结肠炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The ethanolic extract of domesticated Amauroderma rugosum alleviated DSS-induced ulcerative colitis via repairing the intestinal barrier

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The ethanolic extract of domesticated Amauroderma rugosum alleviated DSS-induced ulcerative colitis via repairing the intestinal barrier

Amauroderma rugosum (Blume and T. Nees) Torrend (Ganodermataceae) (A. rugosum) has been found to have anti-inflammatory ability in previous studies. The present study aimed to verify the therapeutic benefits of A. rugosum in the treatment of ulcerative colitis and to investigate its underlying mechanism of action. Acute experimental ulcerative colitis was induced by feeding the mice drinking water supplemented with dextran sodium sulfate (DSS). The findings indicated that the ethanolic extract of domesticated A. rugosum exhibited therapeutic efficacy comparable to Salazosulfapyridine (SASP) in mitigating clinical symptoms and the pathological score of the colon. Furthermore, A. rugosum exhibited the capacity to enhance the expression of tight junction (TJ) proteins, while concurrently decreasing the levels of TNF-ɑ and IL-6. A noteworthy finding is that it exhibited the capability to diminish the nuclear translocation of NF-κB p65. In conclusion, A. rugosum attenuates DSS-induced ulcerative colitis by enhancing intestinal barrier function and inhibiting mucosal inflammation.

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来源期刊

Food Science and Biotechnology FOOD SCIENCE & TECHNOLOGY-

CiteScore

5.40

自引率

3.40%

发文量

174

审稿时长

2.3 months

期刊介绍： The FSB journal covers food chemistry and analysis for compositional and physiological activity changes, food hygiene and toxicology, food microbiology and biotechnology, and food engineering involved in during and after food processing through physical, chemical, and biological ways. Consumer perception and sensory evaluation on processed foods are accepted only when they are relevant to the laboratory research work. As a general rule, manuscripts dealing with analysis and efficacy of extracts from natural resources prior to the processing or without any related food processing may not be considered within the scope of the journal. The FSB journal does not deal with only local interest and a lack of significant scientific merit. The main scope of our journal is seeking for human health and wellness through constructive works and new findings in food science and biotechnology field.