用烯基碘化物和硒粉简便制备 SeCF3 取代的烯烃

IF 1.4 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Haruka Matsui, Yuki Kojima, Koji Hirano
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引用次数: 0

摘要

通过铜介导的烯基碘化物三氟甲基硒化反应,开发了一种 SeCF3 取代烯的合成方法。在 CuI 和 bpy 的存在下,由 Ag 盐、TMSCF3 和市售 Se 粉末原位生成的 AgSeCF3 可以成功地与烯基碘化物偶联,以高化学选择性生成三氟甲基硒烯烃。该反应的底物范围很广,包括来自生物活性分子的烯基碘化物。此外,该反应还证明了放大合成的可行性,从而突出了该方案的实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Facile Preparation of SeCF3-substituted Alkenes from Alkenyl Iodides and Selenium Powder
A synthetic method of SeCF3-substituted alkenes by a copper-mediated trifluoromethylselenolation of alkenyl iodides has been developed. In the presence of CuI and bpy, AgSeCF3 generated in-situ from Ag salt, TMSCF3, and commercially available Se powder, can be successfully coupled with alkenyl iodides to produce the trifluoromethylselenoalkenes with high chemoselectivity. The reaction shows a broad substrate scope including alkenyl iodides derived from biologically active molecules. Moreover, the feasibility of its scale-up synthesis has been demonstrated, thereby underscoring the practicality of the protocol.
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来源期刊
Chemistry Letters
Chemistry Letters 化学-化学综合
CiteScore
3.00
自引率
6.20%
发文量
260
审稿时长
1.2 months
期刊介绍: Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry
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