IL-22 是自身免疫性疾病中的一种重要细胞因子。

IF 3.4 3区医学 Q3 IMMUNOLOGY

Clinical and experimental immunology Pub Date : 2024-04-23 DOI:10.1093/cei/uxae035

Jiajin Li, Zhen Wu, Yuxin Wu, Xin Yu Hu, Jun Yang, Dacheng Zhu, Mingyue Wu, Xin Li, Lutterodt Bentum-Ennin, Wanglai Hu

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引用次数: 0

摘要

白细胞介素-22（IL-22）是一种重要的细胞因子，在包括类风湿性关节炎（RA）、多发性硬化症（MS）和阿尔茨海默病（AD）在内的各种自身免疫性疾病中会出现失调。作为激活众多信号通路的起点，IL-22 在自身免疫性疾病的诱发和发展过程中发挥着重要作用。具体来说，IL-22 信号传导的失衡会干扰其他信号传导途径，造成靶基因的交叉调节，最终导致免疫性疾病的发生。本综述阐述了 IL-22 信号通路与自身免疫性疾病之间的各种联系，重点是对 IL-22 的细胞来源及其对各种细胞类型的影响的最新认识。我们进一步探讨了与靶向 IL-22 相关的药理干预措施的进展，描述了此类治疗策略有望如何开创治疗自身免疫性疾病的新纪元。

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IL-22, a vital cytokine in autoimmune diseases.

Interleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD). As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross regulation of target genes which ultimately leads to the development of immune disorders. This review delineates the various connections between the IL-22 signaling pathway and autoimmune disease, focusing on the latest understanding of the cellular sources of IL-22 and its effects on various cell types. We further explore progress with pharmacological interventions related to targeting IL-22, describing how such therapeutic strategies promise to usher in a new era in the treatment of autoimmune disease.

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来源期刊

Clinical and experimental immunology 医学-免疫学

CiteScore

8.40

自引率

2.20%

发文量

101

审稿时长

3-8 weeks

期刊介绍： Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our understanding of the immunopathology of human disease and/or change clinical practice. The journal is focused on translational and clinical immunology and is among the foremost journals in this field, attracting high-quality papers from across the world. Translation is viewed as a process of applying ideas, insights and discoveries generated through scientific studies to the treatment, prevention or diagnosis of human disease. Clinical immunology has evolved as a field to encompass the application of state-of-the-art technologies such as next-generation sequencing, metagenomics and high-dimensional phenotyping to understand mechanisms that govern the outcomes of clinical trials.