Kedondong (Spondias dulcis Sol. Ex G.Forst) 叶提取物和馏分的体外防晒活性

Rudiyansyah, Rizal Fathurrahman, Endah Sayekti
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引用次数: 0

摘要

过度日晒会导致皮肤发红(红斑)和变黑(色素沉着)。使用防晒霜可以防止这种影响。Kedondong 叶片(Spondias dulcis Sol.众所周知,酚类和类黄酮化合物中的共轭双键能够吸收紫外线辐射,从而降低紫外线对皮肤的照射强度。本研究的目的是根据防晒系数(SPF)、红斑透射值百分比(%Te)和色素沉着透射值百分比(%Tp)确定葛根叶的防晒活性,并确定葛根叶提取物和馏分中的次生代谢物群。研究阶段包括浸渍提取葛藤叶、去叶绿素,然后用正己烷和二氯甲烷进行分馏,得到甲醇提取物、正己烷馏分、二氯甲烷馏分和甲醇馏分。然后对提取物和馏分进行了植物化学测试。植物化学测试表明,甲醇提取物中的次生代谢化合物包括生物碱、酚类、甾体和皂苷。此外,正己烷萃取物中含有类固醇,二氯甲烷萃取物中含有酚类化合物,甲醇萃取物中含有生物碱、酚类和皂苷化合物。使用波长为 200-400 纳米的紫外可见分光光度计进行的防晒活性测试表明,浓度为 120 毫克/升的二氯甲烷馏分属于额外保护类,SPF 值为 7.86±0.23;快速晒黑类,%Te 值为 15.99±0.83;防晒霜类,%Tp 值为 32.72±1.09。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aktivitas Tabir Surya Secara In-Vitro Ekstrak dan Fraksi Daun Kedondong (Spondias dulcis Sol. Ex G.Forst)
Excessive sun exposure to the skin can cause redness (erythema) and darkening of the skin (pigmentation). This effect can be prevented by using sunscreen. Kedondong leaves (Spondias dulcis Sol. Ex G. Forst) can act as a natural sunscreen because they contain secondary metabolite compounds with a conjugated double bond structure (chromophore), including phenolic and flavonoid compounds. The presence of conjugated double bonds in phenolic and flavonoid compounds is known to be able to absorb UV radiation thereby reducing its intensity on the skin. This study aims to determine the sunscreen activity of kedondong leaves based on the Sun Protection Factor (SPF), , the percentage of erythema transmission value (%Te), and the percentage of pigmentation transmission value (%Tp) and determine the secondary metabolite groups in kedondong leaf extracts and fractions. The research stages carried out were extraction of kedondong leaves by maceration, dechlorophyllation, followed by fractionation using n-hexane and dichloromethane, to obtain methanol extract, n-hexane fraction, dichloromethane fraction and methanol fraction. Then phytochemical tests were carried out on the extracts and fractions. Phytochemical tests showed that the secondary metabolite compounds in the methanol extract of kedondong leaves were alkaloids, phenolics, steroids and saponins. Furthermore, in the n-hexane fraction are steroids, the dichloromethane fraction is phenolic compounds, and the methanol fraction is alkaloid, phenolic and saponin compounds. Using a UV-Vis spectrophotometer at a wavelength of 200-400 nm, the sunscreen activity test showed that the dichloromethane fraction at a concentration of 120 mg/L was included in the extra protection category with an SPF value of 7,86±0,23; fast tanning with a %Te value of 15,99±0,83 and sunblock with a %Tp value of 32,72±1,09.
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