小儿肾移植的临床难题：我们对血管紧张素 II I 型受体抗体在小儿肾移植中的作用的认识和未来之路。

IF 1.2 4区医学 Q3 PEDIATRICS

Pediatric Transplantation Pub Date : 2024-04-23 DOI:10.1111/petr.14762

Meghan H Pearl

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引用次数: 0

摘要

血管紧张素 II 1 型受体抗体（AT1R-Abs）是肾移植中研究最深入的非 HLA 抗体之一。这些抗体已被证明在小儿肾移植中很常见，并与抗体介导的排斥反应（AMR）、血管炎症、人类白细胞供体特异性抗体（HLA DSA）的产生和异体移植物丢失有关。随着AT1R-Ab检测越来越容易获得，指导临床实践检测和治疗小儿肾移植受者AT1R-Ab阳性的证据仍然有限。本综述讨论了根据现有证据评估 AT1R-Ab 的临床复杂性。

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Clinical conundrums in pediatric kidney transplantation: What we know about the role of angiotensin II type I receptor antibodies in pediatric kidney transplantation and the path forward.

Antibodies to angiotensin II type 1 receptor (AT1R-Abs) are among the most well-studied non-HLA antibodies in renal transplantation. These antibodies have been shown to be common in pediatric kidney transplantation and associated with antibody-mediated rejection (AMR), vascular inflammation, development of human leukocyte donor-specific antibodies (HLA DSA), and allograft loss. As AT1R-Ab testing becomes more readily accessible, evidence to guide clinical practice for testing and treating AT1R-Ab positivity in pediatric kidney transplant recipients remains limited. This review discusses the clinical complexities of evaluating AT1R-Abs given the current available evidence.

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来源期刊

Pediatric Transplantation 医学-小儿科

CiteScore

2.90

自引率

15.40%

发文量

216

审稿时长

3-8 weeks

期刊介绍： The aim of Pediatric Transplantation is to publish original articles of the highest quality on clinical experience and basic research in transplantation of tissues and solid organs in infants, children and adolescents. The journal seeks to disseminate the latest information widely to all individuals involved in kidney, liver, heart, lung, intestine and stem cell (bone-marrow) transplantation. In addition, the journal publishes focused reviews on topics relevant to pediatric transplantation as well as timely editorial comment on controversial issues.