Hamza Bayhan, Serap Dogan, Begumhan Yilmaz Kardas, Mehmet Emin Diken, Tuncay Dirmenci, Serap Celikler
{"title":"当地特有的 Cirsium steriolepis Petrak 提取物对过氧化氢引起的毒性的综合抗原毒性分析","authors":"Hamza Bayhan, Serap Dogan, Begumhan Yilmaz Kardas, Mehmet Emin Diken, Tuncay Dirmenci, Serap Celikler","doi":"10.1007/s10068-024-01555-7","DOIUrl":null,"url":null,"abstract":"<div><p>Cyto/genotoxicity have been widespread utilized for the safety risk assessment of synthetic/natural chemicals. Plants can protect organisms from harmful effects of xenobiotics. On the other hand, plants can extract toxic molecules from the environment which may disrupt mitosis and cytokinesis. However, the precise role of <i>Cirsium steriolepis</i> during this process is unknown. We showed that <i>steriolepis</i> didn’t cause cyto/genotoxicity. Findings showed powerful inhibition in micronucleus formation and they are safe for healthy human lymphocytes in terms of their capacity to generate chromosomal aberrations. They caused significant increases in sister chromatid exchange (SCE) compared to control but they were able to decrease SCE frequency caused by H<sub>2</sub>O<sub>2</sub>. Additionally, the antibacterial efficiencies of the samples against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> were up to 50% of the effectivity of penicillin/streptomycin. <i>Steriolepis</i> was able to protect the organism from the oxidative damage and didn’t affect the normal developmental phases of <i>Drosophila melanogaster</i>.</p></div>","PeriodicalId":566,"journal":{"name":"Food Science and Biotechnology","volume":"33 13","pages":"3131 - 3152"},"PeriodicalIF":2.4000,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comprehensive antigenotoxic profile of endemic Cirsium steriolepis Petrak extracts against hydrogen peroxide induced toxicity\",\"authors\":\"Hamza Bayhan, Serap Dogan, Begumhan Yilmaz Kardas, Mehmet Emin Diken, Tuncay Dirmenci, Serap Celikler\",\"doi\":\"10.1007/s10068-024-01555-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cyto/genotoxicity have been widespread utilized for the safety risk assessment of synthetic/natural chemicals. Plants can protect organisms from harmful effects of xenobiotics. On the other hand, plants can extract toxic molecules from the environment which may disrupt mitosis and cytokinesis. However, the precise role of <i>Cirsium steriolepis</i> during this process is unknown. We showed that <i>steriolepis</i> didn’t cause cyto/genotoxicity. Findings showed powerful inhibition in micronucleus formation and they are safe for healthy human lymphocytes in terms of their capacity to generate chromosomal aberrations. They caused significant increases in sister chromatid exchange (SCE) compared to control but they were able to decrease SCE frequency caused by H<sub>2</sub>O<sub>2</sub>. Additionally, the antibacterial efficiencies of the samples against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> were up to 50% of the effectivity of penicillin/streptomycin. <i>Steriolepis</i> was able to protect the organism from the oxidative damage and didn’t affect the normal developmental phases of <i>Drosophila melanogaster</i>.</p></div>\",\"PeriodicalId\":566,\"journal\":{\"name\":\"Food Science and Biotechnology\",\"volume\":\"33 13\",\"pages\":\"3131 - 3152\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Science and Biotechnology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10068-024-01555-7\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Science and Biotechnology","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1007/s10068-024-01555-7","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Comprehensive antigenotoxic profile of endemic Cirsium steriolepis Petrak extracts against hydrogen peroxide induced toxicity
Cyto/genotoxicity have been widespread utilized for the safety risk assessment of synthetic/natural chemicals. Plants can protect organisms from harmful effects of xenobiotics. On the other hand, plants can extract toxic molecules from the environment which may disrupt mitosis and cytokinesis. However, the precise role of Cirsium steriolepis during this process is unknown. We showed that steriolepis didn’t cause cyto/genotoxicity. Findings showed powerful inhibition in micronucleus formation and they are safe for healthy human lymphocytes in terms of their capacity to generate chromosomal aberrations. They caused significant increases in sister chromatid exchange (SCE) compared to control but they were able to decrease SCE frequency caused by H2O2. Additionally, the antibacterial efficiencies of the samples against Escherichia coli and Staphylococcus aureus were up to 50% of the effectivity of penicillin/streptomycin. Steriolepis was able to protect the organism from the oxidative damage and didn’t affect the normal developmental phases of Drosophila melanogaster.
期刊介绍：
The FSB journal covers food chemistry and analysis for compositional and physiological activity changes, food hygiene and toxicology, food microbiology and biotechnology, and food engineering involved in during and after food processing through physical, chemical, and biological ways. Consumer perception and sensory evaluation on processed foods are accepted only when they are relevant to the laboratory research work. As a general rule, manuscripts dealing with analysis and efficacy of extracts from natural resources prior to the processing or without any related food processing may not be considered within the scope of the journal. The FSB journal does not deal with only local interest and a lack of significant scientific merit. The main scope of our journal is seeking for human health and wellness through constructive works and new findings in food science and biotechnology field.
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