下尿路感觉机制中的瞬时受体电位通道。

Ruiqiang Gou, Yuanyuan Liu, Li Gou, Shengyan Mi, Xiaonan Li, Yichen Yang, Xiaorong Cheng, Yibao Zhang
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引用次数: 0

摘要

尿液的储存和排泄需要泌尿道和中枢神经系统(CNS)的相互作用网络,而膀胱中的储水和膀胱颈、尿道和尿道外括约肌的出口则是这一网络的中介。通过相互沟通和协调,排尿系统最终呈现出类似开关的活动模式。在颈胸椎和腰骶部,下尿路的脊髓反射通路接受来自尿路神经元的机械感觉输入,调节膀胱收缩活动,从而控制自主排尿。上述任何水平的损伤都可能导致下尿路功能障碍(LUTD),给患者和社会带来巨大负担。嘌呤能受体和瞬时受体电位(TRP)通道的特异性表达被认为在下尿路排尿中发挥着重要作用。本文回顾了有关排尿反射的知识,并描述了TRP通道在排尿过程中的作用和功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transient receptor potential channels in sensory mechanisms of the lower urinary tract.
Urine storage and excretion require a network of interactions in the urinary tract and the central nervous system (CNS), which is mediated by a reservoir of water in the bladder and the outlet to the bladder neck, urethra and external urethral sphincter. Through communicating and coordinating each other, micturition system eventually showed a switch-like activity pattern. At cervicothoracic and lumbosacral spine, the spinal reflex pathway of the lower urinary tract (LUT) received mechanosensory input from the urothelium to regulate the bladder contraction activity, thereby controlled urination voluntarily. Impairment of above-mentioned any level could result in lower urinary tract dysfunction (LUTD), placed a huge burden on patients and society. Specific expression of purinergic receptors and transient receptor potential (TRP) channels are thought to play an important role in urinary excretion in the lower urinary tract. This article reviewed the knowledge about the voiding reflex and described the role and function of TRP channels during voiding.
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