V. Petta, Danai Bisirtzoglou, Efthalia Gkioxari, Ira Michailidou, A. Zetos, Efthymios Andriotis, Kosmas Iliadis, Georgios Polites
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引用次数: 0
摘要
胸腺瘤是一种病因不明的罕见恶性肿瘤,在儿童和年轻人中极为罕见,其发病率在中年时有所上升,并在生命的第七个十年达到高峰。据报道,胸腺瘤幸存者随后会罹患多种肿瘤,包括非霍奇金淋巴瘤(NHL)、软组织肉瘤、胃肠道恶性肿瘤、前列腺癌、乳腺癌、肺癌和皮肤癌。根据癌症登记处已公布的数据,胸腺瘤患者罹患 B 细胞非霍奇金淋巴瘤的风险较高,原因是胸腺瘤或其治疗导致免疫紊乱。非小细胞肺癌是最常见的肺癌类型,也是希腊发病率和死亡率最高的癌症。NSCLC的预后主要取决于早期诊断和最佳治疗方法的选择。我们首次描述了一例罕见的单侧胸腺癌和胸腺瘤同时发生在同一肺部的病例,该病例通过同时对两个病灶进行根治性手术切除获得了成功治疗。胸腺瘤与肺腺癌之间的关联机制尚未明确。然而,胸腺瘤患者必须警惕新恶性肿瘤的发展,因为早期发现和治疗可提供更好的预后。
A rare case of synchronous thymoma type AB and lung adenocarcinoma in a non-smoker middle-aged woman
Thymoma is a rare malignancy of unknown etiology, exceedingly uncommon in children and young adults, which has a prevalence that rises in middle age and presents a peak in the seventh decade of life. A wide variety of subsequent neoplasms have been reported among thymoma survivors, including non-Hodgkin lymphomas (NHL), soft tissue sarcomas, gastrointestinal malignancies, prostate cancer, breast cancer, lung cancer, and skin cancer. According to already published data collected from cancer registries, patients with thymoma have an elevated risk for developing B-cell non-Hodgkin lymphoma, due to immune disturbance arising from the thymoma or its treatment. NSCLC is the most common type of lung cancer and the greatest cause of morbidity and mortality in Greece. The prognosis of NSCLC is based significantly on early diagnosis and selection of the optimal therapeutic approach. We describe, for the first time, a rare case of concomitant thymoma and adenocarcinoma unilaterally in the same lung, which was treated successfully with radical surgical resection of both lesions concurrently. The linking mechanism between thymoma and lung adenocarcinoma has not been clarified yet. However, thymoma patients must be aware of development of new malignancies, as early detection and treatment provide better prognosis.