高尔基体缺陷是溶酶体功能障碍的主要原因之一

Sarah R. Akaaboune, Yanzhuang Wang
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引用次数: 0

摘要

高尔基体在溶酶体的生物生成和溶酶体酶的输送中发挥着至关重要的作用,而溶酶体酶对维持细胞稳态和确保细胞存活至关重要。高尔基体结构和功能的缺陷会严重影响溶酶体的稳态,导致各种溶酶体贮积疾病和神经退行性疾病。在这篇综述中,我们将重点介绍高尔基体重组堆积蛋白(GRASPs)在高尔基体的形成和功能中的作用,强调目前对高尔基体、溶酶体和溶酶体贮积疾病之间关联的理解。此外,我们还讨论了高尔基体功能障碍如何导致溶酶体酶的分泌。本综述旨在提供一份简明的资料,让人们深入了解高尔基体的结构、功能、与疾病相关的缺陷及其对溶酶体生物发生和功能的影响。通过强调高尔基体缺陷是导致各种疾病溶酶体功能障碍的一个未被重视的因素,我们旨在加深对这些错综复杂的细胞过程的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Golgi defect as a major contributor to lysosomal dysfunction
The Golgi apparatus plays a crucial role in lysosome biogenesis and the delivery of lysosomal enzymes, essential for maintaining cellular homeostasis and ensuring cell survival. Deficiencies in Golgi structure and function can profoundly impact lysosomal homeostasis, leading to various lysosomal storage diseases and neurodegenerative disorders. In this review, we highlight the role of the Golgi Reassembly Stacking Proteins (GRASPs) in the formation and function of the Golgi apparatus, emphasizing the current understanding of the association between the Golgi apparatus, lysosomes, and lysosomal storage diseases. Additionally, we discuss how Golgi dysfunction leads to the secretion of lysosomal enzymes. This review aims to serve as a concise resource, offering insights into Golgi structure, function, disease-related defects, and their consequential effects on lysosomal biogenesis and function. By highlighting Golgi defects as an underappreciated contributor to lysosomal dysfunction across various diseases, we aim to enhance comprehension of these intricate cellular processes.
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