基于综合生物标志物反应法探讨土霉素对蚯蚓的毒性

Toxics Pub Date : 2024-04-25 DOI:10.3390/toxics12050310
Haoran Zhou, Xiaoguang Jiao, Yunfei Li
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引用次数: 0

摘要

抗生素污染已成为全球广泛关注的环境问题,其中土霉素污染非常严重。本研究将蚯蚓(Eisenia fetida)暴露于土霉素中,研究土霉素对土壤环境的影响。测定了蚯蚓体内的总蛋白(TP)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、过氧化物酶(POD)、丙二醛(MDA)、谷胱甘肽S-转移酶(GST)和谷胱甘肽过氧化物酶(GPX)等氧化应激指标,并采用综合生物标志物反应(IBR)方法评估了土霉素对蚯蚓的毒性效应。采用与理想解相似的排序偏好技术(TOPSIS)和路径分析模型探讨了应激发生后蚯蚓的生理代谢过程。结果表明,SOD、GPX和GST在抵抗土霉素应激中发挥了重要作用。此外,应激损伤呈现出良好的剂量效应关系,污染物的长期应激对蚯蚓头部组织的损伤最为严重。这些结果为了解土霉素对土壤动物的毒性作用、监测土壤中土霉素的污染状况以及进行生态安全风险评估提供了理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Toxicity of Oxytetracycline in Earthworms (Eisenia fetida) Based on the Integrated Biomarker Response Method
Antibiotic contamination has become a global environmental issue of widespread concern, among which oxytetracycline contamination is very severe. In this study, earthworm (Eisenia fetida) was exposed to oxytetracycline to study its impact on the soil environment. The total protein (TP), catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), malondialdehyde (MDA), glutathione S-transferase (GST), and glutathione peroxidase (GPX) oxidative stress indicators in earthworms were measured, and the integrated biomarker response (IBR) approach was used to evaluate the toxic effect of oxytetracycline on earthworms. A Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) and a path analysis model were used to explore the physiological and metabolic processes of earthworms after stress occurs. The results showed that SOD, GPX, and GST play important roles in resisting oxytetracycline stress. In addition, stress injury showed a good dose–effect relationship, and long-term stress from pollutants resulted in the most serious damage to the head tissue of earthworms. These results provide a theoretical basis for understanding the toxic effect of oxytetracycline on soil animals, monitoring the pollution status of oxytetracycline in soil, and conducting ecological security risk assessment.
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