1 型糖尿病患者β细胞中内源性双链 RNA 编辑功能受损的可能病因。

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-04-25 DOI:10.1111/jdi.14224

Junta Imai

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引用次数: 0

摘要

破坏β细胞内源性dsRNA编辑导致βAdarKO小鼠出现1型糖尿病样表型的拟议机制。β细胞内源性dsRNA编辑的中断会引发IFN反应，从而诱发胰岛炎症和β细胞功能障碍。由 β 细胞功能障碍诱发的高血糖进一步促进了胰岛炎症，这可能是由于 β 细胞工作量增加导致 dsRNA 增加，从而产生了恶性循环。dsRNA编辑障碍与自身免疫介导的1型糖尿病发病机制的结合机制仍有待明确。

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Possible etiological role of impaired endogenous double strand RNA editing in β-cells in type 1 diabetes

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Possible etiological role of impaired endogenous double strand RNA editing in β-cells in type 1 diabetes

Proposed mechanisms by which disruption of endogenous dsRNA editing in β-cells leads to type 1 diabetes-like phenotypes in βAdarKO mice. Disruption of endogenous dsRNA editing in β-cells initiates IFN responses, thereby inducing pancreatic islet inflammation and β-cell dysfunction. Hyperglycemia induced by β-cell dysfunction further promotes islet inflammation, likely via increased dsRNA resulting from increased β-cell workload, thereby producing a vicious cycle. The mechanism by which impairment of dsRNA editing is integrated with autoimmune-mediated pathogenesis of type 1 diabetes remains to be clarified.

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).