成纤维细胞生长因子 23 正在泵送铁：C端-成纤维细胞生长因子23裂解肽及其在铁代谢中的功能。

IF 2.2 3区医学 Q3 PERIPHERAL VASCULAR DISEASE

Current Opinion in Nephrology and Hypertension Pub Date : 2024-04-26 DOI:10.1097/MNH.0000000000000995

Guillaume Courbon, Valentin David

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引用次数: 0

摘要

综述目的铁缺乏不仅调节骨源性磷酸化激素成纤维细胞生长因子 23（FGF23）的产生，而且还调节其裂解，从而产生完整的（iFGF23）和 C-末端（Cter）-FGF23 肽。新的研究表明，除了 iFGF23 的磷酸化作用外，Cter-FGF23 肽在调节全身铁稳态方面也发挥着重要作用。本综述描述了铁代谢与 FGF23 生物学之间复杂的相互作用。最新发现SC-末端（Cter）FGF23 肽能拮抗炎症诱导的低铁血症，以维持血液循环中的生物可用铁库。摘要在本手稿中，我们讨论了 FGF23 如何在缺铁时产生和裂解，以及裂解的 Cter 端 FGF23 肽的主要功能。我们还回顾了慢性肾脏病（CKD）贫血可能产生的影响。

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Fibroblast growth factor 23 is pumping iron: C-terminal-fibroblast growth factor 23 cleaved peptide and its function in iron metabolism.

PURPOSE OF THE REVIEW Iron deficiency regulates the production of the bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23) but also its cleavage, to generate both intact (iFGF23) and C-terminal (Cter)-FGF23 peptides. Novel studies demonstrate that independently of the phosphaturic effects of iFGF23, Cter-FGF23 peptides play an important role in the regulation of systemic iron homeostasis. This review describes the complex interplay between iron metabolism and FGF23 biology. RECENT FINDINGS C-terminal (Cter) FGF23 peptides antagonize inflammation-induced hypoferremia to maintain a pool of bioavailable iron in the circulation. A key mechanism proposed is the down-regulation of the iron-regulating hormone hepcidin by Cter-FGF23. SUMMARY In this manuscript, we discuss how FGF23 is produced and cleaved in response to iron deficiency, and the principal functions of cleaved C-terminal FGF23 peptides. We also review possible implications anemia of chronic kidney disease (CKD).

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来源期刊

Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

6.20%

发文量

132

审稿时长

6-12 weeks

期刊介绍： A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.