线粒体和内质网相关信号转导及其对慢性肝病的中医药调控研究进展

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Yang Zheng, Yi-Hui Zheng, Jiahui Wang, Tie-Jian Zhao, Lei Wang, Tianjian Liang
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引用次数: 0

摘要

内质网(ER)通过线粒体相关ER膜(MAMs)与线粒体相连。MAMs 为内质网和线粒体之间的串联提供了一个框架,在调节细胞钙平衡、脂代谢和细胞死亡方面发挥着至关重要的作用。MAMs 的失调与慢性肝病(CLD)的发展有关。在慢性肝病中,由于细胞应激、炎症和氧化应激等因素,MAMs的结构和功能发生变化,导致线粒体和ER之间的相互作用异常,从而造成肝细胞损伤、纤维化和肝功能受损。中医药在调节 MAMs 信号传导和治疗 CLD 方面取得了一定的研究进展。本文综述了线粒体与ER之间的关联以及中医药干预调控CLD的相关文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progress of mitochondrial and endoplasmic reticulum-associated signaling and its regulation of chronic liver disease by Chinese medicine
The endoplasmic reticulum (ER) is connected to mitochondria through mitochondria-associated ER membranes (MAMs). MAMs provide a framework for crosstalk between the ER and mitochondria, playing a crucial role in regulating cellular calcium balance, lipid metabolism, and cell death. Dysregulation of MAMs is involved in the development of chronic liver disease (CLD). In CLD, changes in MAMs structure and function occur due to factors such as cellular stress, inflammation, and oxidative stress, leading to abnormal interactions between mitochondria and the ER, resulting in liver cell injury, fibrosis, and impaired liver function. Traditional Chinese medicine has shown some research progress in regulating MAMs signaling and treating CLD. This paper reviews the literature on the association between mitochondria and the ER, as well as the intervention of traditional Chinese medicine in regulating CLD.
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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