NEIL3：参与链间DNA交联修复的独特DNA糖基化酶

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2024-04-21 DOI:10.1016/j.dnarep.2024.103680

Leah E. Oswalt , Brandt F. Eichman

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引用次数: 0

摘要

类内切酶 VIII 3（NEIL3）是一种多功能 DNA 糖基化酶，可修复 DNA 上的各种化学修饰。与其他糖基化酶不同，NEIL3 偏爱单链 DNA 内和单/双链 DNA 连接处的病变。除了在氧化 DNA 的碱基切除修复中发挥典型作用外，NEIL3 还能启动依赖复制的链间 DNA 交联修复，作为范可尼贫血症途径的替代方法。本综述概述了我们目前对 NEIL3 的生物功能、在疾病中的作用以及与底物特异性和催化机制有关的三维结构的理解。

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NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair

Endonuclease VIII-like 3 (NEIL3) is a versatile DNA glycosylase that repairs a diverse array of chemical modifications to DNA. Unlike other glycosylases, NEIL3 has a preference for lesions within single-strand DNA and at single/double-strand DNA junctions. Beyond its canonical role in base excision repair of oxidized DNA, NEIL3 initiates replication-dependent interstrand DNA crosslink repair as an alternative to the Fanconi Anemia pathway. This review outlines our current understanding of NEIL3’s biological functions, role in disease, and three-dimensional structure as it pertains to substrate specificity and catalytic mechanism.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.