Xiaoyi Jiang, Kexin Gan, Yuxin Wang, Chao Tao, Xiaojun Liu, Jie Yuan, Zhibin Jin
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引用次数: 0
摘要
传统的 B 型超声成像难以划分具有相似声阻抗的均质软组织,因为反射率取决于界面的声阻抗。声速(SoS)作为一种对生物力学特性改变敏感的定量成像生物标志物,在组织和疾病分化方面具有广阔的应用前景,例如可以划分出具有相似声阻抗的不同乳腺组织类型。与二维(2D)声速图像相比,通过全角度超声扫描获得的三维(3D)容积声速图像能揭示更复杂的组织形态结构,但通常需要一个环形换能器。在本研究中,我们介绍了一种利用手持式线性阵列的三维 SoS 重建系统。该系统在线性阵列的对面安装了一个无源反射器,作为飞行时间(ToF)测量的回声参考,并使用高清摄像头跟踪每组发射-接收数据对应的位置。为了合并这两组 ToF 测量数据和位置跟踪数据,采用了基于体素的重建算法。明胶模型和体外组织的实验结果表明,我们提出的方法非常稳定。此外,实验结果还强调了该系统作为辅助诊断方式的潜力,尤其是在乳腺癌等疾病方面。
Demonstration Study of Reflector-Based Volumetric Speed-of-Sound Imaging With Linear Ultrasound Arrays
Conventional B-mode ultrasound imaging has difficulty in delineating homogeneous soft tissues with similar acoustic impedances, as the reflectivity depends on the acoustic impedance at the interface. As a quantitative imaging biomarker sensitive to alteration of biomechanical properties, speed-of-sound (SoS) holds promising potential for tissue and disease differentiation such as delineation of different breast tissue types with similar acoustic impedance. Compared to two-dimensional (2D) SoS images, three-dimensional (3D) volumetric SoS images achieved through a full-angle ultrasound scan can reveal more intricate morphological structures of tissues; however, they generally require a ring transducer. In this study, we introduce a 3D SoS reconstruction system that utilizes hand-held linear arrays instead. This system employs a passive reflector positioned opposite the linear arrays, serving as an echogenic reference for time-of-flight (ToF) measurements, and a high-definition camera to track the location corresponding to each group of transmit-receive data. To merge these two streams of ToF measurements and location tracking, a voxel-based reconstruction algorithm is implemented. Experimental results with gelatin phantom and ex vivo tissue have demonstrated the stability of our proposed method. Moreover, the results underscore the potential of this system as a complementary diagnostic modality, particularly in the context of diseases such as breast cancer.
期刊介绍:
Ultrasonic Imaging provides rapid publication for original and exceptional papers concerned with the development and application of ultrasonic-imaging technology. Ultrasonic Imaging publishes articles in the following areas: theoretical and experimental aspects of advanced methods and instrumentation for imaging