多发性骨髓瘤中 1q21+ 的诸多方面：发病机制、临床病理特征、预后和临床进展（综述）。

IF 2.5 4区医学 Q3 ONCOLOGY

Oncology Letters Pub Date : 2024-04-09 DOI:10.3892/ol.2024.14391

Na Liu, Zhanzhi Xie, Hao Li, Luqun Wang

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引用次数: 0

摘要

多发性骨髓瘤（MM）是一种恶性肿瘤，其特征是骨髓中异常浆细胞（PC）的克隆性增殖和复发性细胞遗传学异常。全球 MM 的发病率呈上升趋势。1q21+ 与 MM 疾病进展和耐药性的病理生理机制有关。本综述研究了1q21+MM患者的发病机制和临床病理特征，总结了1q21+对MM患者预后的关键数据，阐明了1q21+MM患者的临床治疗意义，以期为临床医生制定针对1q21+的治疗策略提供参考。

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The numerous facets of 1q21+ in multiple myeloma: Pathogenesis, clinicopathological features, prognosis and clinical progress (Review).

Multiple myeloma (MM) is a malignant neoplasm characterized by the clonal proliferation of abnormal plasma cells (PCs) in the bone marrow and recurrent cytogenetic abnormalities. The incidence of MM worldwide is on the rise. 1q21⁺ has been found in ~30-40% of newly diagnosed MM (NDMM) patients.1q21⁺ is associated with the pathophysiological mechanisms of disease progression and drug resistance in MM. In the present review, the pathogenesis and clinicopathological features of MM patients with 1q21⁺ were studied, the key data of 1q21⁺ on the prognosis of MM patients were summarized, and the clinical treatment significance of MM patients with 1q21⁺ was clarified, in order to provide reference for clinicians to develop treatment strategies targeting 1q21⁺.

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来源期刊

Oncology Letters ONCOLOGY-

CiteScore

5.70

自引率

0.00%

发文量

412

审稿时长

2.0 months

期刊介绍： Oncology Letters is a monthly, peer-reviewed journal, available in print and online, that focuses on all aspects of clinical oncology, as well as in vitro and in vivo experimental model systems relevant to the mechanisms of disease. The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original research, reviews and case reports.