结核分枝杆菌与人类之间的基因组相互作用

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY
Prasit Palittapongarnpim, Pornpen Tantivitayakul, Pakorn Aiewsakun, Surakameth Mahasirimongkol, Bharkbhoom Jaemsai
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引用次数: 0

摘要

结核分枝杆菌被许多人认为是最致命的微生物,估计每年病例超过 1 000 万。包括非洲分枝杆菌在内的结核分枝杆菌被分为九大支系和数百个亚支系,每个支系都有不同的地理分布和毒力水平。这种系统地理学模式可能是近期和早期人类迁徙的结果,也可能是细菌与各种人类种群共同进化的结果,这或许可以解释为什么许多关于导致结核病的人类遗传因素的研究无法在不同地区复制。此外,一些研究揭示了人类基因变异和细菌基因型之间的相互作用在决定结核病发展方面的重要意义,这表明存在共同适应。随着人类和细菌全基因组序列数据的增加,人们能够更好地了解这些相互作用,从而为疫苗和其他控制措施的开发提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genomic Interactions Between Mycobacterium tuberculosis and Humans
Mycobacterium tuberculosis is considered by many to be the deadliest microbe, with the estimated annual cases numbering more than 10 million. The bacteria, including Mycobacterium africanum, are classified into nine major lineages and hundreds of sublineages, each with different geographical distributions and levels of virulence. The phylogeographic patterns can be a result of recent and early human migrations as well as coevolution between the bacteria and various human populations, which may explain why many studies on human genetic factors contributing to tuberculosis have not been replicable in different areas. Moreover, several studies have revealed the significance of interactions between human genetic variations and bacterial genotypes in determining the development of tuberculosis, suggesting coadaptation. The increased availability of whole-genome sequence data from both humans and bacteria has enabled a better understanding of these interactions, which can inform the development of vaccines and other control measures.
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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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