疟原虫表面相关抗原（PySRA）通过与巨噬细胞膜上的 CD68 结合调节宿主促炎反应

IF 2.9 3区医学 Q3 IMMUNOLOGY

Infection and Immunity Pub Date : 2024-04-16 DOI:10.1128/iai.00113-24

Xin Feng, Jia-Li Yu, Yi-Fan Sun, Chen-Yan Du, Yao Shen, Lu Zhang, Wei-Zhong Kong, Su Han, Yang Cheng

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引用次数: 0

摘要

疟疾是一种严重危害人类生命和健康的重要蚊媒疾病。据报道，2021 年全球疟疾病例近 2.47 亿例，造成 61.9 万人死亡(1)。疟疾是一种非常复杂的疾病，具有多种病理表现。在感染初期，大多数患者表现为发热、出汗和头痛等全身症状。同时，随着红细胞期寄生虫的增加，会出现脑型疟疾、严重贫血和呼吸困难等症状，从而导致重症疟疾（2-4）。

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Plasmodium yoelii surface-related antigen (PySRA) modulates the host pro-inflammatory responses via binding to CD68 on macrophage membrane

Malaria is an important mosquito-borne disease that seriously endangers human life and health. In 2021, global reports indicate that nearly 247 million malaria cases caused 619,000 deaths (1). Malaria is a highly complex disease with a variety of pathologic manifestations. In the early stages of infection, most patients showed general symptoms such as fever, sweat, and headache. Meanwhile, the symptoms of cerebral malaria, severe anemia, and respiratory distress occurred with the increase in parasites during the erythrocytic stage, leading to severe malaria (2–4).

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来源期刊

Infection and Immunity 医学-传染病学

CiteScore

6.00

自引率

6.50%

发文量

268

审稿时长

3 months

期刊介绍： Infection and Immunity (IAI) provides new insights into the interactions between bacterial, fungal and parasitic pathogens and their hosts. Specific areas of interest include mechanisms of molecular pathogenesis, virulence factors, cellular microbiology, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. IAI also welcomes studies of the microbiome relating to host-pathogen interactions.