肝肾综合征的管理及相关结果:系统性回顾

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jamshid Roozbeh, Shahrokh Ezzatzadegan Jahromi, Mohamad Hossein Rezazadeh, Anahid Hamidianjahromi, Leila Malekmakan
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引用次数: 0

摘要

背景 肝肾综合征(HRS)是一种多器官急性肾损伤,常见于晚期肝病。本研究旨在评估目前治疗 HRS 的方法。方法 作者检索了 PubMed、Scopus 和 Google Scholar 文献。经过质量评估,31 项研究被纳入本综述。采用了系统综述和元分析首选报告项目方法以及人群、干预、比较和结果方案。我们纳入了评估当前 HRS 治疗方法的人类对照试验。两位作者独立筛选纳入文章、提取数据并评估纳入研究的质量。结果 本研究调查了不同治疗方法对 HRS 患者随访效果的影响。我们收集了 440 篇文章,因此有 31 篇文章留在了我们的研究中。其中24篇文章是关于特利加压素与安慰剂或其他治疗方法(米多君/奥曲肽,去甲肾上腺素等)的对比研究,结果显示在17项研究中发现特利加压素的HRS逆转率更高(其中10项具有显著性),2项研究发现特利加压素的终末期肝病评分模型降低率不显著,15项研究显示特利加压素组的死亡率降低(其中4项具有显著性)。结论 本综述显示,特利加压素的 HRS 逆转率明显高于其他治疗方法。研究结果还显示,特利加压素比米多君/奥曲肽和去甲肾上腺素更能有效逆转HRS,提高患者生存率。该研究的所有相关数据均包含在文章中或作为在线补充信息上传。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of hepatorenal syndrome and associated outcomes: a systematic reviews
Background Hepatorenal syndrome (HRS), a multiorgan condition of acute kidney injury, is seen in advanced liver disease. This study aims to evaluate the current treatment for HRS. Methods The authors searched PubMed, Scopus and Google Scholar literature. After quality assessment, 31 studies were included in this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology and the population, intervention, comparison and outcome scheme were used. We included human-controlled trials that evaluate the current treatment for HRS. Two authors independently screened articles for inclusion, extracted data and assessed the quality of included studies. Results This study investigated the studies conducted on the effects of different treatments on follow-up of HRS patients. We gathered 440 articles, so 31 articles remained in our study. Of which 24 articles were conducted on terlipressin versus placebo or other treatments (midodrine/octreotide, norepinephrine, etc) that showed the higher rate of HRS reversal was detected for terlipressin in 17 studies (10 of them were significant), 2 studies achieved an insignificant lower rate of the model for end-stage liver disease score for terlipressin, 15 studies showed a decreased mortality rate in the terlipressin group (4 of them were significant). Conclusion This review showed that terlipressin has a significantly higher reversal rate of HRS than the other treatments. Even the results showed that terlipressin is more efficient than midodrine/octreotide and norepinephrine as a previous medication, in reverse HRS, increasing patient survival. All data relevant to the study are included in the article or uploaded as online supplemental information.
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来源期刊
BMJ Open Gastroenterology
BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.90
自引率
3.20%
发文量
68
审稿时长
2 weeks
期刊介绍: BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.
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