以 Tc-99m-MAG3 为例,无创测量组织中的示踪剂提取效率。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Sarah Wicks, Danielle Levart, Lauren Conway, Neil Heraghty, A Michael Peters
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引用次数: 0

摘要

本研究旨在开发一种测量组织示踪剂提取效率(E)的无创技术,并对 Tc-99m-mercaptoacetyltriglycine (MAG3) 和肾脏进行说明。对 10 名 MAG3 肾造影正常的患者进行了 E 测量。E 是组织清除率与血流量之比(Ki/F)。单光子示踪剂的衰减常数未知,因此无法分别测量 Ki 和 F。然而,通过从相同的感兴趣区(ROI)得出未经衰减校正的 Ki'和 F',这些常数就会抵消,从而得出 E。使用肺部 ROI 测定血液活动,F 是通过第一通道测量的,Ki'则是通过 Gjedde-Patlak-Rutland (GPR) 分析测得的,最高可达 130 秒。由于右心室的干扰,左心室 ROI(LV)不适合测量 F',但在 GPR 分析中使用了左心室 ROI,对早期帧(60-90 秒)中肺和左心室 ROI 产生的各自血池信号的比率进行了调整。在左心室功能正常的情况下,肺ROI低估了4%的F'。胸壁间质活动(I)不影响 F',在 20 分钟时分别占肺和左心室信号的 53% 和 30%,在 130 秒时分别占 12% 和 6%,导致对 Ki 的低估分别为 4% 和 2%。忽略这些对立误差,基于肺ROI的左右肾E分别为43.5 (SD 8)%和47.3 (9)%,基于左心室ROI的GPR分析E分别为44.5 (10.9)%和48.3 (10.6)%。E 可以通过结合一过性血流和 GPR 分析的清除率来测量,在临床和临床研究中都具有潜在价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Noninvasive measurement of tracer extraction efficiency in tissue, illustrated with Tc-99m-MAG3.
The aim of this study is to develop a noninvasive technique for measuring tissue tracer extraction efficiency (E) and illustrate it for Tc-99m-mercaptoacetyltriglycine (MAG3) and kidney. E was measured in 10 patients with normal MAG3 renography. E is the ratio of tissue clearance-to-blood flow (Ki/F). For single-photon tracers, attenuation constants are unknown, so Ki and F cannot be separately measured. However, by deriving attenuation-uncorrected Ki' and F' from the same regions of interests (ROIs), these constants cancel out, giving E. Using a lung ROI for blood activity, F was measured from first-pass and Ki' from Gjedde-Patlak-Rutland (GPR) analysis up to 130 s. Because of interference from right ventricle, a left ventricular ROI (LV) is unsuitable for F' but was used in GPR analysis, making an adjustment for the ratio of respective blood pool signals arising from lung and LV ROIs in early frames (60-90 s). A lung ROI underestimates F' by 4% at normal LV function. Chest wall interstitial activity (I), which does not affect F', amounted to 53 and 30% of the lung and LV signals at 20 min, and 12 and 6% at 130 s, resulting in underestimations of Ki of 4 and 2%, respectively. Ignoring these opposing errors, E based on lung ROI for left and right kidneys was 43.5 (SD 8)% and 47.3 (9)%, and based on LV ROI for GPR analysis was 44.5 (10.9)% and 48.3 (10.6)%. E can be measured by combining blood flow from first-pass with clearance from GPR analysis, and has potential value both clinically and in clinical research.
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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