Ananyaa Dixit, Sumithra N. Unni, Sumitha Prabhu, Sajitha Krishnan PP, Greeshma C. Ravindran
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We also aim to find out whether serum PTX3 is a better marker than high-sensitive CRP (hs-CRP) for DN.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this study, we evaluated serum PTX3 levels in 150 patients which were distributed into three groups that are 50 patients with DN, 50 patients with diabetes mellitus (DM) without DN and 50 controls (not any evidence of DM). DN patients were subdivided: 32 patients with microalbuminuria and 18 patients with macroalbuminuria. Serum PTX3 levels were evaluated using an enzyme-linked immunosorbent assay (ELISA) kit.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>DN group patients had a higher value of PTX3 (<i>p</i> < 0.001) as compared to DM without DN and control groups. hs-CRP levels were higher in DM without DN patients compared to DN patients and controls. PTX3 (<i>p</i> = 0.33) and hs-CRP (<i>p</i> = 0.10) levels among microalbuminuria and macroalbuminuria patients were statistically not significant.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This study concludes that serum PTX3 can be used as a diagnostic marker for DN before the development of apparent chronic kidney disease and PTX3 was found to be a better marker than hs-CRP for diagnosing DN.</p>","PeriodicalId":50328,"journal":{"name":"International Journal of Diabetes in Developing Countries","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of serum pentraxin-3 levels in patients with and without diabetic nephropathy\",\"authors\":\"Ananyaa Dixit, Sumithra N. Unni, Sumitha Prabhu, Sajitha Krishnan PP, Greeshma C. Ravindran\",\"doi\":\"10.1007/s13410-024-01335-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Several studies have reported that increased pentraxin-3 (PTX3) levels are associated with impaired renal function in chronic kidney disease (CKD). PTX3 levels increase progressively with diabetic nephropathy (DN) and may be a biomarker for early diagnosis of DN.</p><h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>The study evaluates serum PTX3 levels and their association with the development of DN. We also aim to find out whether serum PTX3 is a better marker than high-sensitive CRP (hs-CRP) for DN.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>In this study, we evaluated serum PTX3 levels in 150 patients which were distributed into three groups that are 50 patients with DN, 50 patients with diabetes mellitus (DM) without DN and 50 controls (not any evidence of DM). 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Role of serum pentraxin-3 levels in patients with and without diabetic nephropathy
Background
Several studies have reported that increased pentraxin-3 (PTX3) levels are associated with impaired renal function in chronic kidney disease (CKD). PTX3 levels increase progressively with diabetic nephropathy (DN) and may be a biomarker for early diagnosis of DN.
Objective
The study evaluates serum PTX3 levels and their association with the development of DN. We also aim to find out whether serum PTX3 is a better marker than high-sensitive CRP (hs-CRP) for DN.
Methods
In this study, we evaluated serum PTX3 levels in 150 patients which were distributed into three groups that are 50 patients with DN, 50 patients with diabetes mellitus (DM) without DN and 50 controls (not any evidence of DM). DN patients were subdivided: 32 patients with microalbuminuria and 18 patients with macroalbuminuria. Serum PTX3 levels were evaluated using an enzyme-linked immunosorbent assay (ELISA) kit.
Results
DN group patients had a higher value of PTX3 (p < 0.001) as compared to DM without DN and control groups. hs-CRP levels were higher in DM without DN patients compared to DN patients and controls. PTX3 (p = 0.33) and hs-CRP (p = 0.10) levels among microalbuminuria and macroalbuminuria patients were statistically not significant.
Conclusion
This study concludes that serum PTX3 can be used as a diagnostic marker for DN before the development of apparent chronic kidney disease and PTX3 was found to be a better marker than hs-CRP for diagnosing DN.
期刊介绍：
International Journal of Diabetes in Developing Countries is the official journal of Research Society for the Study of Diabetes in India. This is a peer reviewed journal and targets a readership consisting of clinicians, research workers, paramedical personnel, nutritionists and health care personnel working in the field of diabetes. Original research articles focusing on clinical and patient care issues including newer therapies and technologies as well as basic science issues in this field are considered for publication in the journal. Systematic reviews of interest to the above group of readers are also accepted.
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